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Alpha-chiral acetylenes having an all-carbon quaternary center: phase transfer catalyzed enantioselective alpha alkylation of alpha-alkyl-alpha-alkynyl esters



Alpha-chiral acetylenes having an all-carbon quaternary center: phase transfer catalyzed enantioselective alpha alkylation of alpha-alkyl-alpha-alkynyl esters



Angewandte Chemie 48(27): 5014-5017



Going through the phases: The title reaction was found to proceed by an initial base-mediated isomerization to allenyl esters and subsequent phase transfer catalyzed alkylation at the alpha position of the ester (see scheme).

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Accession: 051440224

Download citation: RISBibTeXText

PMID: 19492394

DOI: 10.1002/anie.200901977


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