Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart
Jin, H.; Nass, R.D.; Joudrey, P.J.; Lyon, A.R.; Chemaly, E.R.; Rapti, K.; Akar, F.G.
Biophysical Journal 98(10): 2063-2071
Chronically elevated levels of oxidative stress resulting from increased production and/or impaired scavenging of reactive oxygen species are a hallmark of mitochondrial dysfunction in left ventricular hypertrophy. Recently, oscillations of the mitochondrial membrane potential (DeltaPsi(m)) were mechanistically linked to changes in cellular excitability under conditions of acute oxidative stress produced by laser-induced photooxidation of cardiac myocytes in vitro. Here, we investigate the spatiotemporal dynamics of DeltaPsi(m) within the intact heart during ischemia-reperfusion injury. We hypothesize that altered metabolic properties in left ventricular hypertrophy modulate DeltaPsi(m) spatiotemporal properties and arrhythmia propensity.