+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Amount of bone lengthening affects blood flow recovery and bone mineralization after distraction osteogenesis in a canine cleft palate model

Amount of bone lengthening affects blood flow recovery and bone mineralization after distraction osteogenesis in a canine cleft palate model

Cleft Palate-Craniofacial Journal 47(3): 303-313

Distraction osteogenesis has been applied to the craniofacial region. To reduce the cleft width of patients with cleft lip and palate, alveolar bones are distracted toward the cleft. However, no reports have described limitations to the amount of lengthening that can be achieved by distraction osteogenesis in this area. Therefore, we investigated the healing process following different extents of distraction osteogenesis using a canine cleft palate model. A 10-mm bone defect was made in the palates. A bony segment including the canine was prepared and translocated into the defect area at a rate of 1 mm/d for 6 or 10 days, resulting in two groups (6- and 10-mm groups). Canine pulpal blood flow was monitored for 100 days with Doppler flowmetry. Then, the animals were sacrificed and the regenerated bone area was evaluated radiologically and histologically. Statistical significance was confirmed with the Mann-Whitney rank test. Pulpal blood flow in the 6-mm group recovered to original levels earlier than in the 10-mm group. Cortical bone density in the regenerated bone, measured by peripheral quantitative computed tomography, was significantly greater in the 6-mm group than in the 10-mm group. The amount of regenerated bone in histologic sections was also significantly greater in the 6-mm group. We clearly showed that healing progress depends on the extent of distraction osteogenesis, highlighting the importance of limited distraction osteogenesis in the alveolar area.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 051458502

Download citation: RISBibTeXText

PMID: 20426679

Related references

Amount of Bone Lengthening Affects Blood Flow Recovery and Bone Mineralization After Distraction Osteogenesis in a Canine Cleft Palate Model. The Cleft Palate-Craniofacial Journal 47(3): 303-313, 2010

Observation of pulpal blood flow and bone mineralization after alveolar distraction osteogenesis in a canine cleft model. Kokubyo Gakkai Zasshi. Journal of the Stomatological Society Japan 76(1): 37-44, 2009

Special distraction osteogenesis before bone grafting for alveolar cleft defects to correct maxillary deformities in patients with bilateral cleft lips and palates: distraction osteogenesis performed separately for each bone segment. Journal of Cranio-Maxillo-Facial Surgery 42(5): 623-628, 2014

Distraction osteogenesis for cleft palate closure in a canine model. Archives of Facial Plastic Surgery 7(6): 398-404, 2005

Distraction osteogenesis for segmental bone defect. Physeal change after acute bone shortening followed by gradual lengthening in a rabbit tibia model. Injury 36(12): 1453-1459, 2005

Transpalatal distraction osteogenesis prior to alveolar bone grafting in cleft lip and palate patients. International Journal of Oral and Maxillofacial Surgery 39(8): 761-766, 2010

Bone morphogenetic protein expression in distraction osteogenesis correction for cleft palate in Rhesus monkeys. Hua Xi Kou Qiang Yi Xue Za Zhi 28(4): 425-429, 2010

Telescopic bone plate for use in bone lengthening by distraction osteogenesis. Official Gazette of the United States Patent and Trademark Office Patents 1222(2), 1999

Experimental Study of Immediate Distraction Osteogenesis With Bone Grafting: Amount of the Bone Augmentation and Histomorphological Evaluation. Journal of Oral and Maxillofacial Surgery 65(9-Supp-S): 3600-36000, 2007

Effects of parathyroid hormone on newly regenerated bone during distraction osteogenesis in a rabbit tibial lengthening model. A pilot study. Medicina 42(1): 38-48, 2006

Correlation Between Speech Outcomes and the Amount of Maxillary Advancement After Orthognathic Surgery (Le Fort I Conventional Osteotomy and Distraction Osteogenesis) in Patients With Cleft Lip and Palate. Journal of Craniofacial Surgery 30(6): 1855-1858, 2019

Osteogenesis and angiogenesis in regenerating bone during transverse distraction: quantitative evaluation using a canine model. Clinical Orthopaedics and Related Research 2005(433): 243-250, 2005

Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible. Journal of Oral and Maxillofacial Surgery 70(2): 429-439, 2012

Osseointegration of dental implants placed into canine mandibular bone regenerated by bone transport distraction osteogenesis. International Journal of Oral and Maxillofacial Implants 28(3): 677-686, 2013

Architecture and microstructure of cortical bone in reconstructed canine mandibles after bone transport distraction osteogenesis. Calcified Tissue International 89(5): 379-388, 2011