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Amphiphilic multi-arm block copolymer based on hyperbranched polyester, poly(L-lactide) and poly(ethylene glycol) as a drug delivery carrier

Amphiphilic multi-arm block copolymer based on hyperbranched polyester, poly(L-lactide) and poly(ethylene glycol) as a drug delivery carrier

Macromolecular Bioscience 9(5): 515-524

A novel type of biodegradable/biocompatible amphiphilic hyperbranched copolymer (H40-PLA-b-MPEG) was synthesized. Its micellar properties were studied by DLS, fluorescence spectroscopy and TEM. The drug release profile showed that the H40-PLA-b-MPEG micelles provide an initial burst release, followed by a sustained release of the entrapped hydrophobic model drug over a period of 4 to 58 h. The copolymer degraded hydrolytically within 6 weeks under physiological conditions. The MTT assay showed no obvious cytotoxicity against a human endothelial cell line at a concentration range of 0-400 microg x mL(-1). These results indicate that the H40-PLA-b-MPEG micelles have great potential as hydrophobic drug delivery carriers.

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Accession: 051459195

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PMID: 19089867

DOI: 10.1002/mabi.200800269

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