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An acute exposure to glyphosate-based herbicide alters aromatase levels in testis and sperm nuclear quality

An acute exposure to glyphosate-based herbicide alters aromatase levels in testis and sperm nuclear quality

Environmental Toxicology and Pharmacology 38(1): 131-140

Roundup is the major pesticide used in agriculture worldwide; it is a glyphosate-based herbicide. Its molecular effects are studied following an acute exposure (0.5%) of fifteen 60-day-old male rats during an 8-day period. Endocrine (aromatase, estrogen and androgen receptors, Gper1 in testicular and sperm mRNAs) and testicular functions (organ weights, sperm parameters and expression of the blood-testis barrier markers) were monitored at days 68, 87, and 122 after treatment, spermiogenesis and spermatogenesis. The major disruption is an increase of aromatase mRNA levels at least by 50% in treated rats at all times, as well as the aromatase protein. We have also shown a similar increase of Gper1 expression at day 122 and a light modification of BTB markers. A rise of abnormal sperm morphology and a decrease of the expression of protamine 1 and histone 1 testicular in epididymal sperm are observed despite a normal sperm concentration and motility.

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Accession: 051469012

Download citation: RISBibTeXText

PMID: 24930125

DOI: 10.1016/j.etap.2014.05.007

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