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An efficient enantioselective method for asymmetric Michael addition of nitroalkanes to alpha,beta-unsaturated aldehydes

Wang, Y.; Li, P.; Liang, X.; Zhang, T.Y.; Ye, J.

Chemical Communications 10: 1232-1234

2008


ISSN/ISBN: 1359-7345
PMID: 18309427
DOI: 10.1039/b717000a
Accession: 051480191

The addition of nitroalkanes to alpha,beta-unsaturated aldehydes under the catalysis of (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine and lithium acetate as additive afforded gamma-nitroaldehydes in good yield and up to 97% ee.

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