+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Analgesic activity of catalpol in rodent models of neuropathic pain, and its spinal mechanism



Analgesic activity of catalpol in rodent models of neuropathic pain, and its spinal mechanism



Cell Biochemistry and Biophysics 70(3): 1565-1571



Neuropathic pain is a major health issue that represents considerable social and economic burden worldwidely. In this study, we investigated the potential of catalpol, an iridoid glucoside of Rehmannia glutinosa Steud, to alleviate neuropathic pain. The potential analgesic effects of catalpol were evaluated by chronic constriction injury (CCI) and lumbar 5 spinal nerve ligation (L5 SNL) model. In addition, we explored whether catalpol altered the degree of microglia activation and neuroinflammation in rat spinal cord after CCI induction. Repeated administration of catalpol (1, 5, 25, and 125 mg/kg) reversed mechanical allodynia induced by CCI and L5 SNL in a dose-dependent manner in rats. Levels of activated microglia, activated NF-κB, and proinflammatory cytokines (IL-1β, IL-6, TNF-α) in lumber spinal cord were elevated in rats following CCI induction, and catalpol significantly inhibited these effects. Our results demonstrated that catalpol produces significant antinociceptive action in rodent behavioral models of neuropathic pain and that this effect is associated with modulation of neuroinflammation in spinal cord.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 051514526

Download citation: RISBibTeXText

PMID: 24980862

DOI: 10.1007/s12013-014-0096-0


Related references

Analgesic efficacy in rodent models of neuropathic pain of a muscarinic subtype selective agonist. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 425 13, 2003

The M1/M4 preferring agonist xanomeline is analgesic in rodent models of chronic inflammatory and neuropathic pain via central site of action. Pain 152(12): 2852-2860, 2011

Differential spinal cord gene expression in rodent models of radicular and neuropathic pain. Anesthesiology 104(6): 1283-1292, 2006

Analgesic activity of sodium channel blockers in neuropathic and inflammatory pain models in the rat. Society for Neuroscience Abstracts 20(1-2): 556, 1994

The analgesic activity of the NK-1 receptor antagonist CP99,994 in models of chronic inflammatory and neuropathic pain in the rat. British Journal of Pharmacology 114(PROC Suppl. ): 350P, 1994

Analgesic activity of 3-mono-substituted derivatives of dihydrofuran-2-one in experimental rodent models of pain. Pharmacological Reports 61(5): 807-818, 2010

Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain. European Journal of Pain 10(6): 505-512, 2006

Beyond rodent models of pain: non-human primate models for evaluating novel analgesic therapeutics and elaborating pain mechanisms. Cns and Neurological Disorders Drug Targets 12(8): 1257-1270, 2013

Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats. British Journal of Pharmacology 162(2): 428-440, 2011

In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models. British Journal of Pharmacology 153(2): 390-401, 2008

Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine. European Journal of Pharmacology 735: 17-25, 2014

Spinal GABAergic mechanisms in the effects of spinal cord stimulation in a rodent model of neuropathic pain: is GABA synthesis involved?. Neuromodulation 16(2): 114-120, 2013

Spinal cord stimulation of dorsal columns in a rat model of neuropathic pain: evidence for a segmental spinal mechanism of pain relief. Pain 153(1): 177-183, 2012

Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain. Anesthesiology 107(3): 486-494, 2007

RNA interference in rodent models of neuropathic pain. 2007