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Anthracycline-induced cardiac toxicity more likely in underweight childhood cancer survivors

Anthracycline-induced cardiac toxicity more likely in underweight childhood cancer survivors

Journal of Pediatric Hematology/Oncology 32(5): 411-415

We did a retrospective medical record and echocardiogram review of patients with history of anthracyclines and/or radiation seen in a long-term survivor clinic from 2000-2007. Three hundred eight out of three hundred seventy (83.2%) patients had received at least 1 screening echocardiogram, and 24/308 (7.8%) patients had an abnormal echocardiogram. Observed risk factors for a future abnormal echocardiogram included anthracycline dose > or =250 mg/m2 and underweight status (BMI <5th%) at follow-up. Age, gender, radiation, anthracycline type, history of relapse, and history of stem cell transplant were not risk factors. Our results confirm the dose-dependent risk of anthracyclines, and describe a novel association with underweight status.

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Accession: 051563302

Download citation: RISBibTeXText

PMID: 20495481

DOI: 10.1097/MPH.0b013e3181dccd37

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