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Anthracycline-induced cardiomyopathy

Anthracycline-induced cardiomyopathy

Postgraduate Medicine 120(4): 67-72

Anthracyclines are potent chemotherapeutic agents associated with 3 different forms of cardiomyopathy. Acute cardiomyopathy is seen within 3 months of drug exposure and may take the form of either a reversible myocarditis and pericarditis or an early-onset type and a late-onset type of chronic cardiomyopathy. Chronic anthracycline-induced cardiomyopathy is treated similarly to ischemic cardiomyopathies with beta-blockade and angiotensin-converting enzyme (ACE) inhibition. This review focuses on recent research regarding mechanisms of anthracycline-induced myocardial damage, the noninvasive imaging diagnosis of anthracycline-induced cardiomyopathy, and potential areas of future research regarding genetic screening and selecting individuals at increased risk, with consideration of prophylactic treatment with medications, specifically carvedilol and ACE inhibitors.

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Accession: 051563303

Download citation: RISBibTeXText

PMID: 19020367

DOI: 10.3810/pgm.2008.11.1940

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