+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Anti-inflammatory Effect of Perilla frutescens (L.) Britton var. frutescens Extract in LPS-stimulated RAW 264.7 Macrophages

Anti-inflammatory Effect of Perilla frutescens (L.) Britton var. frutescens Extract in LPS-stimulated RAW 264.7 Macrophages

Preventive Nutrition and Food Science 17(2): 109-115

ISSN/ISBN: 2287-1098

PMID: 24471071

DOI: 10.3746/pnf.2012.17.2.109

This study was designed to investigate the inhibitory effects of Perilla frutescens (L.) Britton var. frutescens extract on the production of inflammation-related mediators (NO, ROS, NF-κB, iNOS and COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in lipopolysaccharide-stimulated RAW 264.7 macrophages. Perilla frutescents (L.) Britton var. frutescens was air-dried and extracted with ethanol. The extract dose-dependently decreased the generation of intracellular reactive oxygen species and dose-dependently increased antioxidant enzyme activities, such as superoxide dismutase, catalase and glutathione peroxidase in lipopolysaccharide stimulated RAW 264.7 macrophages. Also, Perilla frutescens (L.) Britton var. frutescens extract suppressed NO production in lipopolysaccharide-stimulated RAW 264.7 cells. The expressions of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), NF-κB, iNOS and COX-2 were inhibited by the treatment with the extract. Thus, this study shows the Perilla frutescens (L.) Britton var. frutescens extract could be useful for inhibition of the inflammatory process.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 051568282

Download citation: RISBibTeXText

Related references

Glycoglycerolipids from the leaves of Perilla frutescens (L.) Britton (Labiatae) and their anti-inflammatory activities in lipopolysaccharide-stimulated RAW264.7 cells. Phytochemistry 184: 112679, 2021

Perilla frutescens Britton var. frutescens leaves attenuate dextran sulfate sodium-induced acute colitis in mice and lipopolysaccharide-stimulated angiogenic processes in human umbilical vein endothelial cells. Food Science and Biotechnology 29(1): 131-140, 2020

Anti-inflammatory effects of Perilla frutescens leaf extract on lipopolysaccharide-stimulated RAW264.7 cells. Molecular Medicine Reports 10(2): 1077-1083, 2014

Diversity distribution and collection of genetic resources of cultivated and weedy type in Perilla frutescens (L.) Britton var. frutescens and their uses in Indian Himalaya. Genetic Resources and Crop Evolution 55(6): 883-892, 2008

Composition of the Essential Oil, Neutral Volatile Oil and Petroleum Ether Extract of Korean Perilla (Perilla frutescens Britton) Leaves. Asian Journal of Chemistry 24(7): 3221-3224, 2012

Inotropic and lusitropic effects of Perilla frutescens (L.) Britton extract on the rabbit myocardium. Medicina 42(5): 406-412, 2006

Glycoprotein derived from the hot water extract of mint plant, Perilla frutescens Britton. Journal of Agricultural and Food Chemistry 47(2): 468-472, 1999

Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells. Fitoterapia 130: 61-65, 2018

Anti-allergic activity of glycopeptide isolated from Perilla frutescens BRITTON. Journal of Traditional Medicines 18(6): 239-244, 2001

Comparative analysis of chemical compositions of fruits of Perilla frutescens var. arguta and P. frutescens var. frutescens by pre-column derivatization with GC-MS. Zhongguo Zhong Yao Za Zhi 46(23): 6185-6195, 2021

Inhibitory activities of Perilla frutescens britton leaf extract against the growth, migration, and adhesion of human cancer cells. Nutrition Research and Practice 9(1): 11-16, 2015

Volatile oil composition of Indian Perilla Perilla frutescens L Britton collected at different phenophases. 2013

Characteristic aroma-active compounds of Korean perilla (Perilla frutescens Britton) leaf. Journal of Agricultural and Food Chemistry 57(24): 11537-11542, 2009

Perilla ketone: a potent lung toxin from the mint plant, Perilla frutescens Britton. Science, USA 197(4303): 573-574, 1976

Germination rates of perilla (Perilla frutescens (L.) Britton) mericarps stored at 4 degrees C for 1-20 years. Journal of Natural Medicines 64(3): 378-382, 2010