+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Anti-interferon-gamma autoantibody in a patient with disseminated Mycobacterium avium complex



Anti-interferon-gamma autoantibody in a patient with disseminated Mycobacterium avium complex



Journal of Infection and ChemoTherapy 15(2): 118-122



We report the case of a 44-year-old woman with disseminated Mycobacterium avium complex (MAC) infection involving multiple bone lesions despite a normal healthy status until 6 months previously. Because she was suspected to have acquired immunodeficiency, we tested interferon (IFN)-gamma production by peripheral blood mononuclear cells (PBMC) after phytohemagglutinin (PHA) or anti-CD3 stimulation, and found that these cells produced no, or undetectable, levels of IFN-gamma in the presence of the patient's plasma, but produced nearly normal levels of IFN-gamma in the presence of healthy donor plasma. Since the IgG fraction of the patient's plasma was capable of blocking in vitro responses to IFN-gamma, the cause of disseminated MAC infection in this case appeared to be anti-IFN-gamma autoantibodies. To reduce the titer of anti-IFN-gamma autoantibodies, the patient received intravenous immunoglobulin (IVIG). However, titer of autoantibodies changed little compared to that before IVIG administration. According to our literature search, this is only the second case of disseminated MAC infection associated with anti-IFN-gamma autoantibodies in Japan.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 051569768

Download citation: RISBibTeXText

PMID: 19396523

DOI: 10.1007/s10156-008-0662-8


Related references

Disseminated Mycobacterium avium complex infection in a patient with autoantibody to interferon-gamma. Internal Medicine 46(13): 1005-1009, 2007

Recurrence of disseminated Mycobacterium avium complex disease in a patient with anti-gamma interferon autoantibodies by reinfection. Journal of Clinical Microbiology 53(4): 1436-1438, 2015

Disseminated Mycobacterium avium complex infection in a patient carrying autoantibody to interferon-γ. Journal of Infection and ChemoTherapy 19(6): 1152-1157, 2013

Rituximab Restores IFN-γ-STAT1 Function and Ameliorates Disseminated Mycobacterium avium Infection in a Patient with Anti-Interferon-γ Autoantibody. Journal of Clinical Immunology 37(7): 644-649, 2017

Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency. European Journal of Pediatrics 166(9): 981-985, 2007

Late-Onset Disseminated Mycobacterium avium intracellulare Complex Infection (MAC), Cerebral Toxoplasmosis and Salmonella Sepsis in a German Caucasian Patient with Unusual Anti-Interferon-Gamma IgG1 Autoantibodies. Journal of Clinical Immunology 35(4): 361-365, 2015

Effective combination therapy using interferon-gamma and interleukin-2 for disseminated Mycobacterium avium complex infection in a pediatric patient with AIDS. Clinical Infectious Diseases 41(11): E104-E106, 2005

Severe Disseminated Mycobacterium avium Infection in a Patient with a Positive Serum Autoantibody to Interferon-γ. Internal Medicine 55(20): 3053-3058, 2017

Successful HLA-identical bone marrow transplantation in a patient with interferon-gamma receptor 2 deficiency and disseminated Mycobacterium avium complex infection. Journal of Allergy & Clinical Immunology 113(2 Suppl.): S44, 2004

Recurrent, multifocal Mycobacterium avium-intercellulare infection in a patient with interferon-gamma autoantibody. Clinical Infectious Diseases 49(7): E76-E78, 2009

Interferon gamma receptor deficiency in disseminated Mycobacterium avium complex infection. Journal of Investigative Medicine 45(3): 199A, 1997

Chylous ascites, anti-interferon-gamma autoantibody, and angioimmunoblastic T-cell lymphoma: a rare but intriguing connection over Mycobacterium avium. Medical Microbiology and Immunology 208(1): 33-37, 2019

The first US domestic report of disseminated Mycobacterium avium complex and anti-interferon-γ autoantibodies. Journal of Clinical Immunology 34(8): 928-932, 2014

Disseminated Mycobacterium avium and recurrent Salmonella group D infection in a patient with autoantibodies to interferon-gamma. Southeast Asian Journal of Tropical Medicine and Public Health 44(3): 460-467, 2013

IL-12-Independent costimulation pathways for interferon-gamma production in familial disseminated Mycobacterium avium complex infection. Clinical Immunology 91(2): 234-241, 1999