Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4- (1H-imidazol-1-yl) phenyl]prop-2-en-1-ones

Hussain, T.; Siddiqui, H.L.; Zia-ur-Rehman, M.; Masoom Yasinzai, M.; Parvez, M.

European Journal of Medicinal Chemistry 44(11): 4654-4660


ISSN/ISBN: 1768-3254
PMID: 19664864
DOI: 10.1016/j.ejmech.2009.06.038
Accession: 051570428

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A series of new 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones were synthesized by the condensation of various acetophenones with 4-(1H-imidazol-1-yl) benzaldehyde which was itself prepared by the N-arylation of imidazole using hexadecyltrimethylammonium bromide as catalyst for the first time. All the synthesized compounds were subjected to preliminary evaluation for their anti-leishmanial, anti-oxidant and anti-fungal activities. Few of the synthesized compounds showed significant activities.