+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Antibiotic resistance of bacterial biofilms



Antibiotic resistance of bacterial biofilms



International Journal of Antimicrobial Agents 35(4): 322-332



A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and DNA. Bacterial biofilms cause chronic infections because they show increased tolerance to antibiotics and disinfectant chemicals as well as resisting phagocytosis and other components of the body's defence system. The persistence of, for example, staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients is caused by biofilm-growing mucoid strains. Characteristically, gradients of nutrients and oxygen exist from the top to the bottom of biofilms and these gradients are associated with decreased bacterial metabolic activity and increased doubling times of the bacterial cells; it is these more or less dormant cells that are responsible for some of the tolerance to antibiotics. Biofilm growth is associated with an increased level of mutations as well as with quorum-sensing-regulated mechanisms. Conventional resistance mechanisms such as chromosomal beta-lactamase, upregulated efflux pumps and mutations in antibiotic target molecules in bacteria also contribute to the survival of biofilms. Biofilms can be prevented by early aggressive antibiotic prophylaxis or therapy and they can be treated by chronic suppressive therapy. A promising strategy may be the use of enzymes that can dissolve the biofilm matrix (e.g. DNase and alginate lyase) as well as quorum-sensing inhibitors that increase biofilm susceptibility to antibiotics.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 051574430

Download citation: RISBibTeXText

PMID: 20149602

DOI: 10.1016/j.ijantimicag.2009.12.011


Related references

Mechanisms of antibiotic resistance in bacterial biofilms. International Journal of Medical Microbiology 292(2): 107-113, 2002

Persistence of antibiotic resistance plasmids in bacterial biofilms. Evolutionary Applications 10(6): 640-647, 2017

The molecular basis of enhanced antibiotic resistance of bacterial biofilms. Abstracts of the General Meeting of the American Society for Microbiology 102: 24, 2002

Antibiotic-Loaded MoS<sub>2</sub> Nanosheets to Combat Bacterial Resistance via Biofilms Inhibition. Nanotechnology 2017:, 2017

Bacterial biofilms, antibiotic resistance and healthcare-associated infections: a dangerous connection. Microscopy and Microanalysis 21(S6): 38-39, 2015

Antibiotic resistant pathogenic bacteria and their resistance genes in bacterial biofilms. International Journal of Artificial Organs 29(4): 387-394, 2006

Silica-gentamicin nanohybrids: combating antibiotic resistance, bacterial biofilms, and in vivo toxicity. International Journal of Nanomedicine 13: 7939-7957, 2018

Biofilms and antibiotic therapy: is there a role for combating bacterial resistance by the use of novel drug delivery systems?. Advanced Drug Delivery Reviews 57(10): 1539-1550, 2005

Propionibacterial biofilms cannot explain antibiotic resistance but might contribute to some cases of antibiotic recalcitrant acne. British Journal of Dermatology 148(2): 366-367, 2003

Peptide IDR-1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic-resistant bacterial infections. Journal of Peptide Science 21(5): 323-329, 2015

Bacterial resistance to antibiotics. II. Bacterial resistance to streptomycin; effect of acquired resistance to this antibiotic on the morphology of E. coli strains. Annales Pharmaceutiques Francaises 13(5): 386-395, 1955

SARI: surveillance of antibiotic use and bacterial resistance in German intensive care units. Correlation between antibiotic use and the emergence of resistance. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47(4): 345-351, 2004

Antibiotic resistance among bacterial conjunctival pathogens collected in the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) surveillance study. Plos one 13(10): E0205814, 2018

Antibiotic resistance genes in bacterial and bacteriophage fractions of Tunisian and Spanish wastewaters as markers to compare the antibiotic resistance patterns in each population. Environment International 73: 167-175, 2014

Antibiotic resistance of biofilms. Biofouling 10(4): 331-346, 1996