+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Apoptotic effect of tolfenamic acid on MDA-MB-231 breast cancer cells and xenograft tumors



Apoptotic effect of tolfenamic acid on MDA-MB-231 breast cancer cells and xenograft tumors



Journal of Clinical Biochemistry and Nutrition 53(1): 21-26



Recent studies have indicated that non-steroidal anti-inflammatory drug (NSAID), particularly tolfenamic acid, can inhibit proliferation and induce apoptosis invarious cancer cells. Breast cancer represents one-third of all cancers diagnosed in women and is the second leading cause of cancer death in Western European and North American women. In the present study, we investigated the apoptotic effect of tolfenamic acid in MDA-MB-231 estrogen receptor-negative human breast carcinoma cells and in a xenograft tumor model. Treatment of cells with tolfenamic acid significantly decreased cell viability in a concentration-dependent manner. Notably, tolfenamic acid increased apoptosis-related proteins, such as p53 and p21, within 48 h. Furthermore, in vivo experiments showed that tolfenamic acid treatment resulted in a significant reduction in tumor volume over 5 weeks. Immunohistochemistry results showed that apoptosis-related protein induction by tolfenamic acid was significantly higher in the 50 mg/kg-treated group compared to the control group. Together, these results indicate that tolfenamic acid induces apoptosis in MDA-MB-231 breast cancer cells and tumor xenograft model and it may be a potential chemotherapeutic agent against breast cancer.

(PDF emailed within 0-6 h: $19.90)

Accession: 051603212

Download citation: RISBibTeXText

PMID: 23874066

DOI: 10.3164/jcbn.12-78


Related references

Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1. Cancer Science 102(4): 742-748, 2011

Chemopreventive effect of tolfenamic acid on KB human cervical cancer cells and tumor xenograft by downregulating specificity protein 1. European Journal of Cancer Prevention 20(2): 102-111, 2011

Apoptotic Effect of Tolfenamic Acid in KB Human Oral Cancer Cells: Possible Involvement of the p38 MAPK Pathway. Journal of Clinical Biochemistry and Nutrition 47(1): 74-80, 2010

Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells. Tumour Biology 37(2): 2137-2143, 2015

Growth inhibition and apoptotic effect of alpha-eleostearic acid on human breast cancer cells. Journal of Natural Medicines 66(1): 77-84, 2012

Differences in gene expression between endothelial cells isolated from xenograft tumors produced by MCF-7 breast cancer cells or from mammary fat pads. Proceedings of the American Association for Cancer Research Annual Meeting (41): 86, March, 2000

Role of transcription factor Sp1 in the 4-O-methylhonokiol-mediated apoptotic effect on oral squamous cancer cells and xenograft. International Journal of Biochemistry & Cell Biology 64: 287-297, 2016

Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model. Plos One 9(9): E108487-E108487, 2015

Inhibitive effect of 3-bromopyruvic acid on human breast cancer MCF-7 cells involves cell cycle arrest and apoptotic induction. Chinese Medical Journal 122(14): 1681-1685, 2009

Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors. Cancer Biology & Therapy 17(3): 262-271, 2016

Anticancer effect of silibinin on the xenograft model using MDA-MB-468 breast cancer cells. Annals of Surgical Treatment and Research 87(4): 167-173, 2014

The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors. Anti-Cancer Drugs 23(6): 651-658, 2012

The differential effects of cyclophosphamide, epirubicin and 5-fluorouracil on apoptotic marker (CPP-32), pro-apoptotic protein (p21(WAF-1)) and anti-apoptotic protein (bcl-2) in breast cancer cells. Breast Cancer Research and Treatment 80(3): 239-244, 2003

The differential effects of cyclophosphamide, epirubicin and 5-fluorouracil on apoptotic marker , pro-apoptotic protein and anti-apoptotic protein in breast cancer cells. Breast Cancer Research & Treatment 80(3): 239-244, August, 2003

Potent inhibitory effect of δ-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo. Journal of Agricultural and Food Chemistry 62(44): 10752-8, 2015