+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Application of a rat hindlimb model: a prediction of force spaces reachable through stimulation of nerve fascicles

Application of a rat hindlimb model: a prediction of force spaces reachable through stimulation of nerve fascicles

IEEE Transactions on Bio-Medical Engineering 58(12): 3328-3338

A device to generate standing or locomotion through chronically placed electrodes has not been fully developed due in part to limitations of clinical experimentation and the high number of muscle activation inputs of the leg. We investigated the feasibility of functional electrical stimulation paradigms that minimize the input dimensions for controlling the limbs by stimulating at nerve fascicles, utilizing a model of the rat hindlimb, which combined previously collected morphological data with muscle physiological parameters presented herein. As validation of the model, we investigated the suitability of a lumped-parameter model for the prediction of muscle activation during dynamic tasks. Using the validated model, we found that the space of forces producible through activation of muscle groups sharing common nerve fascicles was nonlinearly dependent on the number of discrete muscle groups that could be individually activated (equivalently, the neuroanatomical level of activation). Seven commonly innervated muscle groups were sufficient to produce 78% of the force space producible through individual activation of the 42 modeled hindlimb muscles. This novel, neuroanatomically derived reduction in input dimension emphasizes the potential to simplify controllers for functional electrical stimulation to improve functional recovery after a neuromuscular injury.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 051607635

Download citation: RISBibTeXText

PMID: 21244999

DOI: 10.1109/tbme.2011.2106784

Related references

Sympathetic nerve stimulation attenuates intracellular acidosis and augments force during fatiguing hindlimb muscle contraction. Circulation 90(4 Part 2): I316, 1994

Model based optimal multipolar stimulation without a priori knowledge of nerve structure: application to vagus nerve stimulation. Journal of Neural Engineering 15(4): 046018, 2018

Localization of nerve fascicles with stimulation electrodes used for plexus anesthesia. Biomedizinische Technik. Biomedical Engineering 34 Suppl: 107-108, 1989

Referred pain from intraneural stimulation of muscle fascicles in the median nerve. Pain 18(2): 145-156, 1984

Perceptual dissociations among views of objects, scenes, and reachable spaces. Journal of Experimental Psychology. Human Perception and Performance 45(6): 715-728, 2019

Development of a physiologically-based pharmacokinetic model in the rat hindlimb preparation Estimation of reference spaces. Journal of Pharmacy & Pharmacology 45(Suppl. 2): 1116, 1993

A revised application of the effective nuclear charge model to the prediction of force constants in trigonal-bipyramid XY5 molecules. Spectrochimica Acta Part A: Molecular Spectroscopy 43(5): 703-708, 1987

The application of an effective nuclear charge model to the prediction of valence force constants in trigonal bipyramidal XY5 moleculesIV. Spectrochimica Acta Part A: Molecular Spectroscopy 37(10): 873-878, 1981

Vagus nerve stimulation inhibits the increase in Ca2+ transient and left ventricular force caused by sympathetic nerve stimulation but has no direct effects alone--epicardial Ca2+ fluorescence studies using fura-2 AM in the isolated innervated beating rabbit heart. Experimental Physiology 95(1): 80-92, 2010

Controlled unilateral isometric force generated by epidural spinal cord stimulation in the rat hindlimb. IEEE Transactions on Neural Systems and Rehabilitation Engineering 20(4): 549-556, 2012

Simulation-based prediction model of the draw-bead restraining force and its application to sheet metal forming process. Journal of Materials Processing Technology 187-188: 123-127, 2007

The application of an effective nuclear charge model to the prediction of valence force constants in uranyl tetrachloride and pentafluoride complexesVIII. Spectrochimica Acta Part A: Molecular Spectroscopy 41(8): 1009-1014, 1985

Application of a computational model of vagus nerve stimulation. Acta Neurologica Scandinavica 126(5): 336-343, 2012

Comparison of the sensory threshold in healthy human volunteers with the sensory nerve response of the rat in vitro hindlimb skin and saphenous nerve preparation on cutaneous electrical stimulation. Journal of Hand Surgery 20(4): 437-443, 1995

Response of large hindlimb veins of the dog to sympathetic nerve stimulation. American Journal of Physiology 215(2): 299-307, 1968