+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Application of a shortened inhaled adenosine-5'-monophosphate challenge in young children using the forced oscillation technique



Application of a shortened inhaled adenosine-5'-monophosphate challenge in young children using the forced oscillation technique



Chest 136(1): 184-189



Adenosine-5'-monophosphate (AMP) is an indirect challenge agent thought to reflect allergic airway inflammation. The forced oscillation technique (FOT) is ideal for use in young children and is suitable for inhaled challenge studies in patients who are in this age group. We assessed the agreement between a shortened and a standard AMP challenge and the repeatability of the shortened AMP challenge using FOT as a primary outcome variable. Eighteen children completed a shortened and a standard AMP challenge, and 20 children completed repeated shortened AMP challenges. The children inhaled nebulized AMP tidally for 2 min, following which the presence of wheeze and pulse oximetric saturation (Spo(2)) was recorded prior to FOT measurement. Testing continued until the maximum dose was reached or until wheeze, a decrease in Spo(2) to < 90%, or an increase in respiratory resistance at 8 Hz of 2.0 hPa/s/L or 30% was noted. Concordance was assessed as a binary response, and agreement in provocation concentrations (PCs) causing a response was assessed with intraclass correlations. There was a high degree of concordance between the shortened and standard AMP protocols (94%) and repeated shortened AMP protocols (100%). The mean log(10) PCs displayed a high degree of agreement for both AMP protocols, with intraclass correlation coefficients of 0.94 (95% confidence interval, 0.85 to 0.98) and 0.94 (95% confidence interval, 0.82 to 0.98), respectively. We demonstrated that a shortened AMP challenge that can be applied to young children is comparable to the standard AMP challenge and is highly repeatable. Further studies in young children to assess the clinical role of a shortened AMP challenge using FOT are required.

(PDF emailed within 0-6 h: $19.90)

Accession: 051607689

Download citation: RISBibTeXText

PMID: 19318674

DOI: 10.1378/chest.08-2848



Related references

Histamine challenge test in children reliability of the forced oscillation technique. American Review of Respiratory Disease 133(4 SUPPL): A42, 1986

Forced oscillation technique in infants and young children. Paediatric Respiratory Reviews 6(4): 246-254, 2005

Bronchial challenge test to histamine and methacholine with forced expirations and forced oscillation technique. American Review of Respiratory Disease 143(4 PART 2): A426, 1991

Evaluation of total pulmonary resistance in infants and young children by forced oscillation technique. Journal of Allergy and Clinical Immunology 51(2): 96-96, 1973

Application of the forced oscillation technique in diagnosing and monitoring asthma in preschool children. Advances in Respiratory Medicine 2019, 2019

Effect of inhaled salbutamol hemisuccinate on adenosine 5-monophosphate challenge in asthmatics. European Respiratory Journal 12(Supplement 29): 22s, 1998

Forced oscillation technique is equivalent to plethysmography for dose response curve to inhaled carbachol. American Review of Respiratory Disease 135(4 PART 2): A323, 1987

Modifications in forced vital capacity during adenosine monophosphate-induced bronchoconstriction in asthma: relationship with the response to methacholine and the effect of inhaled corticosteroids. Annals of Allergy, Asthma and Immunology 102(5): 393-399, 2009

Effect of inhaled beclomethasone dipropionate on isocapnic hyperventilation with cold air in asthmatics, measured with forced oscillation technique. European Respiratory Journal 10(3): 665-671, 1997

Asthma diagnosis and treatment - 1007. Clinical application of forced oscillation technique for children with asthma. World Allergy Organization Journal 6 Suppl 1: P7, 2013

Clinical Application of the Forced Oscillation Technique. Internal Medicine 55(6): 559-566, 2016

Comparison of the forced oscillation technique and the interrupter technique for assessing airway obstruction and its reversibility in children. American Journal of Respiratory and Critical Care Medicine 164(6): 965-972, 2001

Comparison of three inhaled non-steroidal anti-inflammatory drugs on the airway response to sodium metabisulphite and adenosine 5'-monophosphate challenge in asthma. Thorax 51(8): 799-804, 1996

Histamine challenge test in children using forced oscillation to measure total respiratory resistance. Chest 92(2): 313-318, 1987

The forced oscillation technique in children with respiratory disease. Pediatric Pulmonology 1(5): 256-261, 1985