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Application of a water-soluble pyridyl disulfide amine linker for use in Cu-free click bioconjugation

Application of a water-soluble pyridyl disulfide amine linker for use in Cu-free click bioconjugation

Tetrahedron Letters 52(33): 4316-4319

Described herein is the design and synthesis of a discrete heterobifunctional PEG-based pyridyl disulfide/amine-containing linker that can be used in the Cu-free click preparation of bioconjugates. The title PEG-based pyridyl disulfide amine linker is a potentially useful reagent for preparing water-soluble disulfide-linked cargos. It may be particularly valuable in expanding the field of Cu-free click-based bioconjugations to include reductively labile antibody, polymer, or nanoparticle-based drug conjugates.

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Accession: 051607811

Download citation: RISBibTeXText

PMID: 21826118

DOI: 10.1016/j.tetlet.2011.06.042

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