+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Application of alpha-lipoic acid in clinical practice



Application of alpha-lipoic acid in clinical practice



Likars'ka Sprava 2012(7-8): 20-28



In the article literature data about application of alpha-lipoic acid in medical practice are summarized. The article presents characteristic of chemical structure and functional activity of alpha-lipoic acid. LA is marketed primarily as a "weight loss" and "energy" supplement and has been branded as antioxidants. Later LA has been the subject of numerous research studies and clinical trials. LA was shown to be hepatoprotective, to improve liver circulation and treat chronic liver diseases, including jaundice hepatitis, cirrhosis, and hepatic coma, to treat diabetes, and diabetic neuropathy to alter carbohydrate metabolism, atherosclerosis, coronary atherosclerosis and many others diseases. One of the most studied clinical uses of LA is the treatment of diabetes and diabetic neuropathy LA has also been used experimentally and/or clinically to prevent organ dysfunction, reduce endothelial dysfunction and improve albuminuria, treat or prevent cardiovascular disease. LA is "small" drug with very big potential.

(PDF emailed within 1 workday: $29.90)

Accession: 051607983

Download citation: RISBibTeXText

PMID: 22768734


Related references

Use of DL- -alpha-lipoic acid, D- -alpha-lipoic acid, alpha-lipoic acid in reduced or oxidized form or salts for treating circulatory disorders. Official Gazette of the United States Patent & Trademark Office Patents 1200(4): 2873, July 22, 1997

Should it be safer to use a redox couple, both with (R)-alpha-lipoic acid combined with (R)-dihydrolipoic acid for avoiding prooxidant action of alpha-lipoic acid?. Medical Hypotheses 68(5): 1178-1178, 2006

The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle. European Journal of Pharmaceutics and Biopharmaceutics 86(2): 251-259, 2014

Metabolic significance of alpha-lipoic acid. V. Comparative action of alpha-lipoic acid, vitamin B 12 and cocarboxylase on metabolism of copper and iron and on aminoacidurias. (Further observations). Arquivo de Patologia 35: 91-97, 1963

Alpha-lipoic acid potently inhibits peroxynitrite-mediated DNA strand breakage and hydroxyl radical formation: implications for the neuroprotective effects of alpha-lipoic acid. Molecular and Cellular Biochemistry 323(1-2): 131-138, 2009

Metabolic significance of alpha-lipoic acid. IV. Action of alpha-lipoic acid on ceruloplasmin and transferrin in different pathological conditions. (Preliminary report). Arquivo de Patologia 35: 3-19, 1963

Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. Free Radical Research 31(3): 171-179, 1999

Metabolic Significance of Alpha-Lipoic Acid. 3. Alpha-Lipoic Acid and Iron Metabolism. (Preliminary Note). Jornal Da Sociedade das Ciencias Medicas de Lisboa 127: 15-52, 1963

Studies on the metabolism of alpha -lipoic acid in childhood. 2. Urinary excretion of alpha -lipoic acid in children. J. Vitaminol., Japan. 11: 54-59, 1965

Decomposition of alpha-lipoic acid derivatives by photoirradiation-formation of dihydrolipoic acid from alpha-lipoic acid-. Biochemistry and Molecular Biology International 38(1): 51-59, 1996

Metabolic significance of alpha-lipoic acid. Comparison of the action of a-lipoic acid, vitamin B12 and cocarboxyl-ase on copper and iron metabolism and on amino acid elimination. Arq Patol 35(1): 91-97, 1963

Pharmaceutical composition containing R-alpha-lipoic acid or S-alpha-lipoic acid as active ingredient. Official Gazette of the United States Patent & Trademark Office Patents 1208(3): 2381, March 17, 1998

Pharmaceutical compositions containing R-alpha-lipoic acid or S-alpha-lipoic acid as active ingredient. Official Gazette of the United States Patent & Trademark Office Patents 1249(1), Aug 7, 2001

Formation of a new acetoxy derivative of alpha-lipoic acid by mild reaction of beta-lipoic acid with acetic anhydride. Journal of Vitaminology 12(3): 244-249, 1966