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Asc1, a WD-repeat protein, is required for hyphal development and virulence in Candida albicans

Asc1, a WD-repeat protein, is required for hyphal development and virulence in Candida albicans

Acta Biochimica et Biophysica Sinica 42(11): 793-800

ISSN/ISBN: 1672-9145

PMID: 20929924

DOI: 10.1093/abbs/gmq093

Candida albicans is a human pathogenic fungus which can undergo a morphological transition from yeast to hyphae in response to a variety of environmental stimuli. We analyzed a C. albicans Asc1 (Absence of growth Suppressor of Cyp1) protein which is entirely composed of seven repeats of the WD domain, and is conserved from fungi to metazoan. Deleting the ASC1 in C. albicans led to a profound defect in hyphal development under hypha-inducing conditions examined. Furthermore, deletion of the ASC1 attenuated virulence of C. albicans in a mouse model of systemic infection. These data strongly suggested that the conserved WD-repeat protein Asc1 is required for morphogenesis and pathogenesis of C. albicans.

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Accession: 051644306

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