+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Assessment of cardiac function and myocardial morphology using small animal Look-Locker inversion recovery (SALLI) MRI in rats

Assessment of cardiac function and myocardial morphology using small animal Look-Locker inversion recovery (SALLI) MRI in rats

Journal of Visualized Experiments 2013(77):

Small animal magnetic resonance imaging is an important tool to study cardiac function and changes in myocardial tissue. The high heart rates of small animals (200 to 600 beats/min) have previously limited the role of CMR imaging. Small animal Look-Locker inversion recovery (SALLI) is a T1 mapping sequence for small animals to overcome this problem. T1 maps provide quantitative information about tissue alterations and contrast agent kinetics. It is also possible to detect diffuse myocardial processes such as interstitial fibrosis or edema. Furthermore, from a single set of image data, it is possible to examine heart function and myocardial scarring by generating cine and inversion recovery-prepared late gadolinium enhancement-type MR images. The presented video shows step-by-step the procedures to perform small animal CMR imaging. Here it is presented with a healthy Sprague-Dawley rat, however naturally it can be extended to different cardiac small animal models.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 051659059

Download citation: RISBibTeXText

PMID: 23912668

DOI: 10.3791/50397

Related references

Small animal Look-Locker inversion recovery (SALLI) for simultaneous generation of cardiac T1 maps and cine and inversion recovery-prepared images at high heart rates: initial experience. Radiology 261(1): 258-265, 2011

Assessment of diffuse myocardial fibrosis in rats using small-animal Look-Locker inversion recovery T1 mapping. Circulation. Cardiovascular Imaging 4(6): 636-640, 2011

Quantitative assessment of hepatic function: modified look-locker inversion recovery (MOLLI) sequence for T1 mapping on Gd-EOB-DTPA-enhanced liver MR imaging. European Radiology 26(6): 1775-1782, 2016

Impact of thoracic surgery on cardiac morphology and function in small animal models of heart disease: a cardiac MRI study in rats. Plos one 8(8): E68275, 2013

Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. Journal of Cardiovascular Magnetic Resonance 12: 69, 2010

Inversion-recovery single-shot cardiac MRI for the assessment of myocardial infarction at 1.5 T with a dedicated cardiac coil. British Journal of Radiology 85(1017): E709-E715, 2012

Accuracy, precision, and reproducibility of myocardial T1 mapping: A comparison of four T1 estimation algorithms for modified look-locker inversion recovery (MOLLI). Magnetic Resonance in Medicine 78(5): 1746-1756, 2017

Modified look-locker inversion recovery T1 mapping indices: assessment of accuracy and reproducibility between magnetic resonance scanners. Journal of Cardiovascular Magnetic Resonance 15: 64, 2013

Inversion group (IG) fitting: A new T1 mapping method for modified look-locker inversion recovery (MOLLI) that allows arbitrary inversion groupings and rest periods (including no rest period). Magnetic Resonance in Medicine 75(6): 2332-2340, 2016

Evaluation of nonscarred myocardial T1 value using contrast-enhanced look-locker cardiac MRI and its relationship to cardiac function in dilated cardiomyopathy: Comparison of 1.5 and 3.0 Tesla MRI. Journal of Magnetic Resonance Imaging 38(6): 1395-1401, 2013

Effect of stromal cell-derived factor-1 on myocardial apoptosis and cardiac function recovery in rats with acute myocardial infarction. Experimental and Therapeutic Medicine 12(5): 3282-3286, 2016

Assessment of left ventricular myocardial scar in infiltrative and non-ischemic cardiac diseases by free breathing three dimensional phase sensitive inversion recovery (PSIR) TurboFLASH. International Journal of Cardiovascular Imaging 27(4): 527-537, 2011

Myocardial morphology and cardiac function in rats with renal failure. Japanese Circulation Journal 64(8): 606-610, 2000

Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magnetic Resonance in Medicine 52(1): 141-146, 2004

Consideration of slice profiles in inversion recovery Look-Locker relaxation parameter mapping. Magnetic Resonance Imaging 32(8): 1021-1030, 2014