Assessment of serum (1->3) -beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis

Wiederhold, N.P.; Najvar, L.K.; Vallor, A.C.; Kirkpatrick, W.R.; Bocanegra, R.; Molina, D.; Olivo, M.; Graybill, J.R.; Patterson, T.F.

Antimicrobial Agents and ChemoTherapy 52(3): 1176-1178

2008


ISSN/ISBN: 0066-4804
PMID: 18160526
DOI: 10.1128/aac.01425-07
Accession: 051665719

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Abstract
Serum (1-->3)-beta-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1-->3)-beta-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.