+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer

Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer

Plos One 5(4): E10061

We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), a population-based, case-control study. The analysis was restricted to 364 invasive serous ovarian cancer cases and 761 controls of white, non-Hispanic race. Statistical analysis was two staged: a screen using marginal Bayes factors (BFs) for 484 SNPs and a modeling stage in which we calculated multivariate adjusted posterior probabilities of association for 77 SNPs that passed the screen. These probabilities were conditional on subject age at diagnosis/interview, batch, a DNA quality metric and genotypes of other SNPs and allowed for uncertainty in the genetic parameterizations of the SNPs and number of associated SNPs. Six SNPs had Bayes factors greater than 10 in favor of an association with invasive serous ovarian cancer. These included rs5762746 (median OR(odds ratio)(per allele) = 0.66; 95% credible interval (CI) = 0.44-1.00) and rs6005835 (median OR(per allele) = 0.69; 95% CI = 0.53-0.91) in CHEK2, rs2078486 (median OR(per allele) = 1.65; 95% CI = 1.21-2.25) and rs12951053 (median OR(per allele) = 1.65; 95% CI = 1.20-2.26) in TP53, rs411697 (median OR (rare homozygote) = 0.53; 95% CI = 0.35 - 0.79) in BACH1 and rs10131 (median OR( rare homozygote) = not estimable) in LIG4. The six most highly associated SNPs are either predicted to be functionally significant or are in LD with such a variant. The variants in TP53 were confirmed to be associated in a large follow-up study. Based on our findings, further follow-up of the DNA repair and response pathways in a larger dataset is warranted to confirm these results.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 051671543

Download citation: RISBibTeXText

PMID: 20386703

Related references

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Plos Genetics 6(7): E1001016, 2010

Common variants in mismatch repair genes and risk of invasive ovarian cancer. Carcinogenesis 27(11): 2235-2242, 2006

Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium. Plos One 6(5): E19642-E19642, 2011

Association of polymorphisms in glutathione-S-transferase and DNA repair genes with ovarian cancer risk in the Russian population. Genetika 48(7): 901-904, 2012

Polymorphisms in the FGF2 gene and risk of serous ovarian cancer: results from the ovarian cancer association consortium. Twin Research and Human Genetics 12(3): 269-275, 2009

Association between genetic polymorphisms of inflammatory response genes and the risk of ovarian cancer. Journal of the Formosan Medical Association 115(1): 31-37, 2017

Anti-Mullerian hormone and risk of invasive serous ovarian cancer. Cancer Causes and Control 25(5): 583-589, 2015

Breast cancer risk associated with genotype polymorphism of oxidative DNA damage repair genes A multigenic study of base excision repair and transcription-coupled repair in cancer susceptibility. Proceedings of the American Association for Cancer Research Annual Meeting 43: 245, 2002

Inherited common variants in mitochondrial DNA and invasive serous epithelial ovarian cancer risk. Bmc Research Notes 6: 425, 2014

An association of selected ERCC2 and ERCC5 genes polymorphisms, the level of oxidative DNA damage and its repair efficiency with a risk of colorectal cancer in Polish population. Cancer Biomarkers 15(4): 413-423, 2016

ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study. Cancer Epidemiology, Biomarkers and Prevention 19(1): 245-250, 2010

Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the ovarian cancer association consortium pooled analysis. British Journal of Cancer 98(2): 282-288, 2008

Comprehensive SNP scan of DNA repair and DNA damage response genes reveal multiple susceptibility loci conferring risk to tobacco associated leukoplakia and oral cancer. Plos One 8(2): E56952, 2013

Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium. Journal of the National Cancer Institute 106(2): Djt431, 2014

Synchronous ovarian granulosa cell tumor and uterine serous carcinoma: a rare association of a high-risk endometrial cancer with anestrogenic ovarian tumor. Gynecologic Oncology 103(3): 1164-1168, 2006