+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Association between XRCC1 polymorphism 399 G->A and glioma among Caucasians: a systematic review and meta-analysis

Association between XRCC1 polymorphism 399 G->A and glioma among Caucasians: a systematic review and meta-analysis

Bmc Medical Genetics 13: 97

The x-ray cross complementing group 1 gene (XRCC1) is crucial to proper repair of DNA damage such as single-strand DNA breaks. A non-synonymous polymorphism in XRCC1, 399 G → A, has been shown to reduce effectiveness of such DNA repair and has been associated with the risk of certain cancers. The known risk for glioma from high dose ionizing radiation makes associations between this polymorphism and glioma of particular interest. A systematic literature review and meta-analysis was conducted to explore the association between XRCC1 399 G → A and glioma. Subgroup analyses by grade, gender, genotyping method, country in which study was conducted, and study size were conducted when data were available and validity of the results were assessed by influence analyses and exploration of potential publication bias. Six studies were eligible for meta-analysis including data on 2,362 Caucasian glioma cases and 3,085 Caucasian controls. Pooled analysis yielded a significant association between the variant of interest and risk of glioma (OR = 1.17, 95% CI: 1.05-1.30) which was found to be disproportionately driven by a single study. Exclusion of this study, in an influence analysis, produced no statistically significant evidence of association with glioma (OR = 1.10, 95% CI: 0.98-1.23), and no evidence of publication bias. This meta-analysis does not suggest a major role of the XRCC1 399 G → A polymorphism in influencing risk of glioma among Caucasians. Future studies should report data separately for glioma subtypes to permit stratified analyses for Grade III and Grade IV glioma and examine other polymorphisms in this gene.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 051672278

Download citation: RISBibTeXText

PMID: 23101479

DOI: 10.1186/1471-2350-13-97

Related references

Association between XRCC1 polymorphism 399 G-A and glioma among Caucasians a systematic review and meta-analysis. BMC Medical Genetics 13(1): 97, 2012

Association between XRCC1 Arg280His polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis. Genetics and Molecular Research 14(2): 7122-7129, 2015

Association between X-ray repair cross-complementing group 1(XRCC1) Arg399Gln polymorphism and endometriosis: A systematic review and meta-analysis. European Journal of Obstetrics Gynecology and Reproductive Biology 218: 12-20, 2017

Association between the XRCC1 Arg194Trp polymorphism and glioma risk: an updated meta-analysis. Asian Pacific Journal of Cancer Prevention 15(17): 7419-7424, 2014

Association between GSTP1 Ile105Val polymorphism and glioma risk: a systematic review and meta-analysis. Tumour Biology 35(1): 493-499, 2014

Lack of association between EGF +61A>G polymorphism and melanoma susceptibility in Caucasians: a HuGE review and meta-analysis. Gene 515(2): 359-366, 2013

A functional polymorphism in XRCC1 is associated with glioma risk: evidence from a meta-analysis. Molecular Biology Reports 40(1): 567-572, 2013

Reappraisal of XRCC1 Arg194Trp polymorphism and glioma risk: a cumulative meta-analysis. Oncotarget 8(13): 21599-21608, 2017

Re: The effectiveness of exercise for the prevention and treatment of antenatal depression: systematic review with meta-analysis; Association and prediction of amniotic fluid measurements for adverse pregnancy outcome: systematic review and meta-analysis; Does induction of labour increase the risk of caesarean section? A systematic review and meta analysis of trials in women with intact membranes. Bjog 122(4): 590-591, 2015

Association between polymorphisms in XRCC1 gene and treatment outcomes of patients with advanced gastric cancer: a systematic review and meta-analysis. Plos one 9(1): E85357, 2014

Genetic Association of XRCC1 Gene rs1799782, rs25487 and rs25489 Polymorphisms with Risk of Thyroid Cancer: a Systematic Review and Meta-Analysis. Asian Pacific Journal of Cancer Prevention 18(1): 263-270, 2017

The XRCC1 Arg194Trp polymorphism is not a risk factor for glioma: A meta-analysis involving 1,440 cases and 2,562 controls. Experimental and Therapeutic Medicine 4(6): 1057-1062, 2012

XRCC1 Arg280His polymorphism and glioma risk: A meta-analysis involving 1439 cases and 2564 controls. Pakistan Journal of Medical Sciences 29(1): 37-42, 2013

Association between XRCC1 gene polymorphisms and risk of glioma development: a meta-analysis. Asian Pacific Journal of Cancer Prevention 13(9): 4783-4788, 2012

The association of PTPN22 rs2476601 polymorphism and CTLA-4 rs231775 polymorphism with LADA risks: a systematic review and meta-analysis. Acta Diabetologica 51(5): 691-703, 2014