+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Association of atherosclerotic risk factors with carotid adventitial thickness assessed by ultrasonography

Association of atherosclerotic risk factors with carotid adventitial thickness assessed by ultrasonography

Journal of Clinical Ultrasound 37(6): 333-341

There is increasing evidence that adventitial inflammation may participate in atherosclerosis development. The aim of this study was to investigate which atherosclerotic risk factors correlated with carotid adventitial thickness (AT) and to compare them with those associated with carotid intima-media thickness (IMT). We also set out to test the hypothesis that there is a significant correlation between IMT and AT in the carotid arteries. The far carotid artery wall IMT and AT were measured by high-resolution B-mode ultrasound in 128 persons (mean, 65 +/- 8 years). A number of conventional and novel, clinically and laboratory-derived risk factors were assessed. Significant correlation (r = 0.35, p < 0.0001) was demonstrated between the IMT and AT. The stepwise forward multiple regression analysis revealed correlations between IMT and leukocyte count, C-reactive protein level, and hypertension, whereas the Chlamydia (C.) pneumoniae IgA antibodies and fibrinogen levels, gender, and smoking correlated merely with AT. The homocysteine/methionine ratio correlated with both IMT and AT. The association between IMT and AT may reflect an interaction between intimal, medial, and adventitial pathology. Different risk factors are associated with the increased AT or IMT. It is possible that inflammation and some chronic infections, such as those induced by C. pneumoniae, could have a marked influence on adventitial cell proliferation.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 051682090

Download citation: RISBibTeXText

PMID: 19455698

DOI: 10.1002/jcu.20585

Related references

Atherosclerotic risk factors and adventitial thickness in carotid arteries. European Journal of Neurology 10(Suppl. 1): 46-47, 2003

Risk factors related to the wall thickness of carotid artery assessed by ultrasonography. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 31(4): 303-309, 1994

Tu-P9:341 The atherosclerotic burden, assessed by carotid ultrasonography, in low-risk patients with dyslipidemia. Atherosclerosis Suppl.s 7(3): 259-260, 2006

Left carotid adventitial vasa vasorum signal correlates directly with age and with left carotid intima-media thickness in individuals without atheromatous risk factors. Cardiovascular Ultrasound 13: 20, 2015

Associations of cardiovascular risk factors, carotid intima-media thickness and left ventricular mass with inter-adventitial diameters of the common carotid artery: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 218(2): 344-349, 2011

Ultrasonographically assessed maximum carotid artery wall thickness in Mexico City residents and Mexican Americans living in San Antonio, Texas. Association with diabetes and cardiovascular risk factors. Arteriosclerosis, Thrombosis, and Vascular Biology 16(11): 1388-1392, 1996

Association of transient ischemic attack/stroke symptoms assessed by standardized questionnaire and algorithm with cerebrovascular risk factors and carotid artery wall thickness. The ARIC Study, 1987-1989. American Journal of Epidemiology 144(9): 857-866, 1996

Serum autoantibodies to actin are associated with carotid artery wall adventitial thickness assessed using B-mode ultrasound. Folia Neuropathologica 41(3): 145-148, 2003

Carotid intima-media thickness and stiffness are independent risk factors for atherosclerotic diseases. Journal of Investigative Medicine 58(6): 786-790, 2010

Association of 10-Year Atherosclerotic Cardiovascular Disease Risk Score with Carotid Intima-Media Thickness and Plaque. Korean Journal of Family Medicine 36(6): 310-315, 2015

Prevalence of potential risk factors for stroke assessed by transesophageal echocardiography and carotid ultrasonography: The SPARC study. Mayo Clinic Proceedings 74(9): 862-869, 1999

Carotid artery intima media thickness in relation with atherosclerotic risk factors in patients with type 2 diabetes mellitus. Journal of the Association of Physicians of India 60: 20-24, 2012

Increased intima media thickness and atherosclerotic plaques in the carotid artery as risk factors for silent brain infarcts. Journal of Stroke and Cerebrovascular Diseases 16(1): 14-20, 2007

Increased levels of platelet activation markers are positively associated with carotid wall thickness and other atherosclerotic risk factors in obese patients. Thrombosis and Haemostasis 106(4): 683-692, 2011

Atherosclerotic plaque volume and composition in symptomatic carotid arteries assessed with multidetector CT angiography; relationship with severity of stenosis and cardiovascular risk factors. European Radiology 19(9): 2294-2301, 2009