+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Association of race/ethnicity with visual outcomes following acute optic neuritis: an analysis of the Optic Neuritis Treatment Trial



Association of race/ethnicity with visual outcomes following acute optic neuritis: an analysis of the Optic Neuritis Treatment Trial



JAMA Ophthalmology 132(4): 421-427



IMPORTANCE Retrospective studies have demonstrated disparate outcomes following acute optic neuritis in individuals of African descent compared with individuals of white race/ethnicity. However, published analyses of the prospectively collected Optic Neuritis Treatment Trial (ONTT) data identified no association between worse visual outcomes and black race/ethnicity. OBJECTIVES To investigate the associations of age, sex, and race/ethnicity with visual outcomes following acute optic neuritis through application of longitudinal data analysis techniques to the ONTT data set. DESIGN Secondary analysis of the ONTT (a prospective randomized controlled trial) data set. Our models included effects of treatment (placebo, oral prednisone, or intravenous methylprednisolone), time, and treatment × time interaction, as well as demographic covariates of age, sex, and race/ethnicity. SETTING AND PARTICIPANTS The ONTT data were collected at multiple centers in the United States. Patients of black (n = 58) and white (n = 388) race/ethnicity with acute optic neuritis who enrolled in the ONTT within 8 days of symptom onset were included in analyses. MAIN OUTCOMES AND MEASURES The contrast sensitivity and visual acuity (logMAR) in the affected eye were modeled using 2-stage mixed-effects regression techniques. All available follow-up data from baseline to 15 to 18 years were included. RESULTS The data identified no relationship of age, sex, or treatment with contrast sensitivity or visual acuity outcomes. Race/ethnicity was significantly related to contrast sensitivity (P < .001) and visual acuity (P < .001) during a 15-year period following acute optic neuritis, with black race/ethnicity being associated with worse scores for both. CONCLUSIONS AND RELEVANCE Race/ethnicity seems to be associated with contrast sensitivity and visual acuity outcomes in affected eyes following acute optic neuritis. To our knowledge, this is the largest cohort of black race/ethnicity with acute optic neuritis to be studied and represents the first evidence from a prospectively collected data set to support a hypothesis of race/ethnicity-dependent visual outcomes of acute optic neuritis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 051686893

Download citation: RISBibTeXText

PMID: 24557028

DOI: 10.1001/jamaophthalmol.2013.7995


Related references

Baseline visual field profile of optic neuritis. The experience of the optic neuritis treatment trial. Optic Neuritis Study Group. Archives of Ophthalmology 111(2): 231-234, 1993

Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group. Archives of Ophthalmology 115(12): 1545-1552, 1997

The SKILL Card test in optic neuritis: experience of the Optic Neuritis Treatment Trial. Smith-Kettlewell Institute Low Luminance. Optic Neuritis Study Group. Journal of Neuro-Ophthalmology 21(2): 124-131, 2001

The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group. Archives of Ophthalmology 109(12): 1673-1678, 1991

Visual field profile of optic neuritis: a final follow-up report from the optic neuritis treatment trial from baseline through 15 years. Archives of Ophthalmology 128(3): 330-337, 2010

Visual field reading center optic neuritis treatment trial the optic neuritis study group. Investigative Ophthalmology & Visual Science 31(4 ABSTR ISSUE): 609, 1990

Visual function 15 years after optic neuritis: a final follow-up report from the Optic Neuritis Treatment Trial. Ophthalmology 115(6): 1079-1082.E5, 2008

Visual Field Profile of Optic Neuritis. One-Year Follow-up in the Optic Neuritis Treatment Trial. Journal of Neuro-Ophthalmology 15(4): 257, 1995

Visual function 5 years after optic neuritis: Experience of the optic neuritis treatment trial: Beck RW, Trobe JD, Moke PS, et al. Arch Ophthalmol 115:1545, 1997. Journal of Oral and Maxillofacial Surgery 56(8): 1007-1008, 1998

Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial. American Journal of Ophthalmology 137(1): 77-83, 2004

The course of visual recovery after optic neuritis. Experience of the Optic Neuritis Treatment Trial. Ophthalmology 101(11): 1771-1778, 1994

Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial. Journal of Neuro-Ophthalmology 17(1): 18-23; Quiz 24-8, 1997

Visual symptoms after optic neuritis: results from the Optic Neuritis Treatment Trial. Survey of Ophthalmology 42(5): 491, 1998

A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group. New England Journal of Medicine 326(9): 581-588, 1992

Fellow eye abnormalities in acute unilateral optic neuritis. Experience of the optic neuritis treatment trial. Ophthalmology 100(5): 691-7; Discussion 697-8, 1993