+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Atherosclerosis and oxidative stress



Atherosclerosis and oxidative stress



Histology and Histopathology 23(3): 381-390



This review focuses on the morphological features of atherosclerosis and the involvement of oxidative stress in the initiation and progression of this disease. There is now consensus that atherosclerosis represents a state of heightened oxidative stress characterized by lipid and protein in the vascular wall. Reactive oxygen species (ROS) are key mediators of signaling pathways that underlie vascular inflammation in atherogenesis, starting from the initiation of fatty streak development, through lesion progression, to ultimate plaque rupture. Plaque rupture and thrombosis result in the acute clinical complications of myocardial infarction and stroke. Many data support the notion that ROS released from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase (MPO), xanthine oxidase (XO), lipoxygenase (LO), nitric oxide synthase (NOS) and enhanced ROS production from dysfunctional mitochondrial respiratory chain, indeed, have a causatory role in atherosclerosis and other vascular diseases. Moreover, oxidative modifications in the arterial wall can contribute to the arteriosclerosis when the balance between oxidants and antioxidants shifts in favour of the former. Therefore, it is important to consider sources of oxidants in the context of available antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase and transferases thiol-disulfide oxidoreductases and peroxiredoxins. Here, we review also the mechanisms in which they are involved in order to accelerate the pace of the discovery and facilitate development of novel therapeutic approaches.

(PDF emailed within 1 workday: $29.90)

Accession: 051700503

Download citation: RISBibTeXText

PMID: 18072094


Related references

Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation. Antioxidants 8(3), 2019

Oxidative Stress in Atherosclerosis Development The Central Role of LDL and Oxidative Burst. Endocrine Metabolic & Immune Disorders - Drug Targets 12(4): 351-360, 2012

Oxidative stress in atherosclerosis development: the central role of LDL and oxidative burst. Endocrine, Metabolic and Immune Disorders Drug Targets 12(4): 351-360, 2013

Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice. Lipids in Health and Disease 17(1): 220, 2018

Atherosclerosis and oxidative stress. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 45(3): 287-290, 2008

Oxidative stress and atherosclerosis. Orvosi Hetilap 156(28): 1115-1119, 2015

Oxidative Stress in Atherosclerosis. Current Atherosclerosis Reports 19(11): 42, 2018

Oxidative stress in atherosclerosis. Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 107(3): 502-511, 2004

Oxidative stress and atherosclerosis. Nihon Rinsho. Japanese Journal of Clinical Medicine 55 Suppl: 752-756, 1997

Oxidative stress, AGE, and atherosclerosis. Kidney International. Supplement: S17-S26, 2007

Oxidative stress and atherosclerosis. Pathophysiology 13(3): 129-142, 2006

The role of oxidative stress in atherosclerosis. Hellenic Journal of Cardiology 50(5): 402-409, 2009

Oxidative stress of platelet and atherosclerosis. Sheng Li Ke Xue Jin Zhan 42(1): 33-38, 2013

Nox enzymes and oxidative stress in atherosclerosis. Frontiers in Bioscience 4: 651-670, 2013

Insights into oxidative stress and atherosclerosis. Canadian Journal of Cardiology 16 Suppl D: 2d-4d, 2000