+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Autologous serum 50% eyedrops in the treatment of persistent corneal epithelial defects



Autologous serum 50% eyedrops in the treatment of persistent corneal epithelial defects



Cornea 28(10): 1104-1108



To evaluate the success rate of treating persistent corneal epithelial defects using 50% autologous serum eyedrops. We reviewed the medical records of all patients seen at our institution from September 2004 to May 2007 who had persistent corneal epithelial defects that were nonresponsive to conventional medical treatment and that were treated with 50% autologous serum eyedrops. We also correlated the defect duration prior to initiation of serum therapy with rate of epithelial healing. A total of 25 eyes of 25 patients failed conventional medical therapy for treatment of a persistent corneal epithelial defect and were treated with 50% autologous serum eyedrops every 2 hours while awake. All corneas were neurotrophic, with the etiologies being herpetic (11 eyes), postkeratoplasty (8 eyes), postkeratorefractive surgery (1 eyes), diabetic (1 eye), post-chemical burn (1 eye), and unknown (3 eyes). The median duration of the epithelial defects prior to initiation of autologous serum eyedrops was 13.9 weeks (range 0.29-52 weeks). After institution of autologous serum therapy, 23 of the 25 eyes healed in a mean time of 22.4 days. Seventeen eyes (68.0%) healed within 4 weeks (mean 1.7 weeks) of starting therapy with 50% autologous serum eyedrops. The number of days required for healing was associated with the length of time the defect was open prior to initiation of serum drops (r = 0.68, P < 0.001). The use of 50% autologous serum eyedrops appears to be an efficacious medical treatment modality for persistent corneal epithelial defects that are recalcitrant to conventional medical therapy.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 051724480

Download citation: RISBibTeXText

PMID: 19730088

DOI: 10.1097/ico.0b013e3181a2a7f6


Related references

Treatment of Persistent Corneal Epithelial Defects by Autologous Serum. ARVO Annual Meeting Abstract Search and Program Planner : Abstract No 1693, 2002

Autologous serum eye drops for the treatment of persistent corneal epithelial defects. Journal of the College of Physicians and Surgeons--Pakistan 23(10): 737-739, 2013

Sterility of non-preserved autologous serum drops for treatment of persistent corneal epithelial defects. Der Ophthalmologe 101(7): 705-709, 2004

Autologous Serum Eye Drops Combined With Silicone Hydrogen Lenses for the Treatment of Postinfectious Corneal Persistent Epithelial Defects. Eye and Contact Lens 43(4): 225-229, 2017

Treatment of Persistent Corneal Epithelial Defects After Vitreoretinal Surgery: Autologous Serum Eye Drops or a Bandage Contact Lens?. Cornea 27(9): 1097-1098, 2008

The use of autologous serum tears in persistent corneal epithelial defects. Eye 18(6): 609-614, 2004

Therapeutic outcomes of combined topical autologous serum eye drops with silicone-hydrogel soft contact lenses in the treatment of corneal persistent epithelial defects: A preliminary study. Contact Lens and Anterior Eye 39(6): 425-430, 2016

Deep corneal calcification associated with preservative-free eyedrops and persistent epithelial defects. Cornea 27(3): 292-296, 2008

Serum eyedrops, a therapy for corneal epithelial defects?. International Ophthalmology 17(Suppl. ): 5, 1993

Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology 106(10): 1984-1989, 1999

Treatment of persistent epithelial defects using autologous serum application. Archivos de la Sociedad Espanola de Oftalmologia 79(11): 537-542, 2004

Therapeutic effect of umbilical cord serum eyedrops for persistent corneal epithelial defect. Korean Journal of Ophthalmology 19(3): 174-178, 2005

Autologous serum eyedrops for dry eyes and epithelial defects: Clinical and in vitro toxicity studies. British Journal of Ophthalmology 85(10): 1188-1197, 2001

Treatment of persistent corneal epithelial disorders with human plasma fibronectin eyedrops. Chinese Journal of Ophthalmology 26(1): 21-23, 1990

Combined application of autologous serum eye drops and silicone hydrogel lenses for the treatment of persistent epithelial defects. Eye and Contact Lens 37(6): 370-373, 2011