+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

B7-H4 expression associates with cancer progression and predicts patient's survival in human esophageal squamous cell carcinoma



B7-H4 expression associates with cancer progression and predicts patient's survival in human esophageal squamous cell carcinoma



Cancer Immunology, ImmunoTherapy 60(7): 1047-1055



A retrospective cohort study including 112 patients suffering from esophageal squamous cell carcinoma (ESCC) was performed to investigate the expression of B7-H4 in ESCC and determine its association with patient's clinicopathological parameters and survival. Expression levels of B7-H4 on tumor cells and densities of tumor infiltrating lymphocytes (TILs) in the surgical specimens of ESCC tissues were characterized using immunohistochemical assays. Uni- and multivariate analyses were performed to evaluate the prognostic value of B7-H4 expression levels and densities of TILs in tumor sections. Positive B7-H4 immunostaining was observed in 107 of 112 (95.5%) of ESCC tissue sections. We further divided all patients into two major subgroups, a lower B7-H4 expression group with 46 patients and a higher B7-H4 expression group with 66 patients. We found that expression levels of B7-H4 on tumor cells were significantly correlated with patient's gender (P = 0.0288), distant metastasis (P = 0.0500), and TNM stage (P = 0.0258). Moreover, tumor cell B7-H4 expression was inversely correlated with densities of CD3(+) T cells in tumor nest (P = 0.0424) and CD8(+) T cells in tumor stroma (P = 0.0229). The overall survival rate of the patients with higher B7-H4 expression was significantly worse than that of the patients with lower B7-H4 expression (P = 0.0105, Hazard Ratio: 1.854, 95%CI:1.152-2.902). Markers of cell-mediated immune responses such as CD3, CD8, and T-bet were associated with better patient survival. The present study demonstrated that B7-H4 expression in human ESCC is associated with cancer progression, reduced tumor immunosurveillance and worse patient outcomes. B7-H4 can serve as a novel prognostic predictor for human ESCC and a potential target for the immune therapy against this malignancy.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 051740749

Download citation: RISBibTeXText

PMID: 21519829

DOI: 10.1007/s00262-011-1017-3


Related references

Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma. Cellular Physiology and Biochemistry 39(1): 395-406, 2016

B7-H1 expression associates with tumor invasion and predicts patient's survival in human esophageal cancer. International Journal of Clinical and Experimental Pathology 7(9): 6015-6023, 2015

Expression of long non-coding RNA ZEB1-AS1 in esophageal squamous cell carcinoma and its correlation with tumor progression and patient survival. International Journal of Clinical and Experimental Pathology 8(9): 11871-6, 2016

Epithelial-to-mesenchymal transition in human esophageal cancer associates with tumor progression and patient's survival. International Journal of Clinical and Experimental Pathology 7(10): 6943-6949, 2015

Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma. World Journal of Gastroenterology 19(18): 2772-2780, 2013

High MLL2 expression predicts poor prognosis and promotes tumor progression by inducing EMT in esophageal squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology, 2018

Cyclin D1 expression predicts postoperative distant metastasis and survival in resectable esophageal squamous cell carcinoma. Oncotarget 7(21): 31088-31096, 2016

HOXA13 promotes cancer cell growth and predicts poor survival of patients with esophageal squamous cell carcinoma. Cancer Research 69(12): 4969-4973, 2009

Increased WNT6 expression in tumor cells predicts unfavorable survival in esophageal squamous cell carcinoma patients. International Journal of Clinical and Experimental Pathology 8(9): 11421-7, 2015

NOTCH1 expression predicts patient prognosis in esophageal squamous cell cancer. European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes 51(3-4): 101-107, 2014

Overexpressed PTOV1 associates with tumorigenesis and progression of esophageal squamous cell carcinoma. Tumour Biology 39(6): 1010428317705013-1010428317705013, 2017

B7-H3 expression associates with tumor invasion and patient's poor survival in human esophageal cancer. American Journal of Translational Research 7(12): 2646-2660, 2016

Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma. Clinical Laboratory 64(5): 669-675, 2018

High endothelin-converting enzyme-1 expression independently predicts poor survival of patients with esophageal squamous cell carcinoma. Tumour Biology 39(9): 1010428317725922-1010428317725922, 2017

High expression of zinc-binding protein-89 predicts decreased survival in esophageal squamous cell cancer. Annals of Thoracic Surgery 97(6): 1966-1973, 2014