Section 52

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Wang, G-Yu.; Lv, Q-Hua.; Dong, Q.; Xu, R-Zhen.; Dong, Q-Hua. 2009: Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice. Journal of Asian Natural Products Research 11(3): 219-228
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Zhao, Y.; Tan, Y.; Wu, G.; Liu, L.; Wang, Y.; Luo, Y.; Shi, J.; Huang, H. 2011: Berbamine overcomes imatinib-induced neutropenia and permits cytogenetic responses in Chinese patients with chronic-phase chronic myeloid leukemia. International Journal of Hematology 94(2): 156-162
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Lin, T.-Y.; Lin, Y.-W.; Lu, C.-W.; Huang, S.-K.; Wang, S.-J. 2013: Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral Cortex. Plos one 8(6): E67215
Zhang, Q.; Xiao, X.; Feng, K.; Wang, T.; Li, W.; Yuan, T.; Sun, X.; Sun, Q.; Xiang, H.; Wang, H. 2011: Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism. Evidence-Based Complementary and Alternative Medicine: Ecam 2011
Alzamora, R.; O'Mahony, F.; Ko, W.-H.; Yip, T.W.-N.; Carter, D.; Irnaten, M.; Harvey, B.J. 2011: Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels. Frontiers in Physiology 2: 33
Wu, C-Ming.; Li, T-Mao.; Tan, T-Wei.; Fong, Y-Chin.; Tang, C-Hsin. 2013: Berberine Reduces the Metastasis of Chondrosarcoma by Modulating the α v β 3 Integrin and the PKC δ , c-Src, and AP-1 Signaling Pathways. Evidence-BasedComplementaryandAlternativeMedicine:Ecam 2013: 423164
Fu, L.; Chen, W.; Guo, W.; Wang, J.; Tian, Y.; Shi, D.; Zhang, X.; Qiu, H.; Xiao, X.; Kang, T.; Huang, W.; Wang, S.; Deng, W. 2013: Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth. Plos one 8(7): E69240
Hsu, Y.-Y.; Chen, C.-S.; Wu, S.-N.; Jong, Y.-J.; Lo, Y.-C. 2012: Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 46(5): 415-425
Liu, S.-W.; Li, Y.; Li, H.-R.; Ma, W.-B.; Pan, T.-C.; Zhu, L.-Y.; Ye, W.-C.; Wang, L.-W.; Chen, L.-X. 2011: Berberine activates volume-sensitive chloride channel in human colorectal carcinoma cells. Sheng Li Xue Bao: 63(6): 517-524
Albring, K.F.; Weidemüller, J.; Mittag, S.; Weiske, J.ör.; Friedrich, K.; Geroni, M.C.; Lombardi, P.; Huber, O. 2013: Berberine acts as a natural inhibitor of Wnt/β-catenin signaling--identification of more active 13-arylalkyl derivatives. Biofactors 39(6): 652-662
Cok, A.; Plaisier, C.; Salie, M.J.; Oram, D.S.; Chenge, J.; Louters, L.L. 2011: Berberine acutely activates the glucose transport activity of GLUT1. Biochimie 93(7): 1187-1192
Zhou, L.; Wang, X.; Shao, L.; Yang, Y.; Shang, W.; Yuan, G.; Jiang, B.; Li, F.; Tang, J.; Jing, H.; Chen, M. 2008: Berberine acutely inhibits insulin secretion from beta-cells through 3',5'-cyclic adenosine 5'-monophosphate signaling pathway. Endocrinology 149(9): 4510-4518
Li, Z-Qiang.; Zuo, D-Ying.; Qie, X-Di.; Qi, H.; Zhao, M-Qi.; Wu, Y-Liang. 2012: Berberine acutely inhibits the digestion of maltose in the intestine. Journal of Ethnopharmacology 142(2): 474-480
Megyesi, M.ón.; Biczók, L.ó 2007: Berberine alkaloid as a sensitive fluorescent probe for bile salt aggregates. Journal of Physical Chemistry. B 111(20): 5635-5639
Wang, L-Hong.; Li, X-Lian.; Li, Q.; Fu, Y.; Yu, H-Jing.; Sun, Y-Qian.; Zhang, L.; Shan, H-Li. 2012: Berberine alleviates ischemic arrhythmias via recovering depressed I(to) and I(Ca) currents in diabetic rats. Phytomedicine: International Journal of PhytoTherapy and Phytopharmacology 19(3-4): 206-210
Moghaddam, H.K.; Baluchnejadmojarad, T.; Roghani, M.; Khaksari, M.; Norouzi, P.; Ahooie, M.; Mahboobi, F. 2014: Berberine ameliorate oxidative stress and astrogliosis in the hippocampus of STZ-induced diabetic rats. Molecular Neurobiology 49(2): 820-826
Lee, I.-A.; Hyun, Y.-J.; Kim, D.-H. 2010: Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation. European Journal of Pharmacology 648(1-3): 162-170
Zhao, H.; Zhang, T.; Xia, C.; Shi, L.; Wang, S.; Zheng, X.; Hu, T.; Zhang, B. 2014: Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling. Journal of Cellular and Molecular Medicine 18(2): 283-292
Wan, X.; Chen, X.; Liu, L.; Zhao, Y.; Huang, W.-J.; Zhang, Q.; Miao, G.-G.; Chen, W.; Xie, H.-G.; Cao, C.-C. 2013: Berberine ameliorates chronic kidney injury caused by atherosclerotic renovascular disease through the suppression of NFκB signaling pathway in rats. Plos one 8(3): E59794
Kim, S.O.; Kim, H.J. 2013: Berberine ameliorates cold and mechanical allodynia in a rat model of diabetic neuropathy. Journal of Medicinal Food 16(6): 511-517
Wang, Z.; Chen, Z.; Yang, S.; Wang, Y.; Huang, Z.; Gao, J.; Tu, S.; Rao, Z. 2014: Berberine ameliorates collagen-induced arthritis in rats associated with anti-inflammatory and anti-angiogenic effects. Inflammation 37(5): 1789-1798
Li, H.; Li, X.-L.; Zhang, M.; Xu, H.; Wang, C.-C.; Wang, S.; Duan, R.-S. 2014: Berberine ameliorates experimental autoimmune neuritis by suppressing both cellular and humoral immunity. Scandinavian Journal of Immunology 79(1): 12-19
Xie, X.; Li, W.; Lan, T.; Liu, W.; Peng, J.; Huang, K.; Huang, J.; Shen, X.; Liu, P.; Huang, H. 2011: Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway. Endocrine Journal 58(9): 761-768
Gu, L.; Li, N.; Gong, J.; Li, Q.; Zhu, W.; Li, J. 2011: Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia. Journal of Infectious Diseases 203(11): 1602-1612
Tan, S.; Yu, W.; Lin, Z.; Chen, Q.; Shi, J.; Dong, Y.; Duan, K.; Bai, X.; Xu, L.; Yu, Z.; Li, J.; Li, N. 2015: Berberine ameliorates intestinal mucosal barrier damage induced by peritoneal air exposure. Biological and Pharmaceutical Bulletin 38(1): 122-126
Tang, L.Q.; Wang, F.L.; Zhu, L.N.; Lv, F.; Liu, S.; Zhang, S.T. 2013: Berberine ameliorates renal injury by regulating G proteins-AC- cAMP signaling in diabetic rats with nephropathy. Molecular Biology Reports 40(6): 3913-3923
Lan, T.; Shen, X.; Liu, P.; Liu, W.; Xu, S.; Xie, X.; Jiang, Q.; Li, W.; Huang, H. 2010: Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. Archives of Biochemistry and Biophysics 502(2): 112-120
Wang, F.-M.; Yang, Y.-J.; Ma, L.-L.; Tian, X.-J.; He, Y.-Q. 2014: Berberine ameliorates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats. Nephrology 19(9): 542-551
Liang, H.-Y.; Chen, T.; Yan, H.-T.; Huang, Z.; Tang, L.-J. 2014: Berberine ameliorates severe acute pancreatitis‑induced intestinal barrier dysfunction via a myosin light chain phosphorylation‑dependent pathway. Molecular Medicine Reports 9(5): 1827-1833
Li, Y.-H.; Yang, P.; Kong, W.-J.; Wang, Y.-X.; Hu, C.-Q.; Zuo, Z.-Y.; Wang, Y.-M.; Gao, H.; Gao, L.-M.; Feng, Y.-C.; Du, N.-N.; Liu, Y.; Song, D.-Q.; Jiang, J.-D. 2009: Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. Journal of Medicinal Chemistry 52(2): 492-501
Tang, J.; Feng, Y.; Tsao, S.; Wang, N.; Curtain, R.; Wang, Y. 2009: Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. Journal of Ethnopharmacology 126(1): 5-17
Sengupta, D.; Chowdhury, K.D.; Sarkar, A.; Paul, S.; Sadhukhan, G.C. 2014: Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma. Biochimica et Biophysica Acta 1840(1): 219-244
Khan, M.; Giessrigl, B.; Vonach, C.; Madlener, S.; Prinz, S.; Herbaceck, I.; Hölzl, C.; Bauer, S.; Viola, K.; Mikulits, W.; Quereshi, R.A.; Knasmüller, S.; Grusch, M.; Kopp, B.; Krupitza, G. 2010: Berberine and a Berberis lycium extract inactivate Cdc25A and induce alpha-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis. Mutation Research 683(1-2): 123-130
Lei, G.; Dan, H.; Jinhua, L.; Wei, Y.; Song, G.; Li, W. 2011: Berberine and itraconazole are not synergistic in vitro against Aspergillus fumigatus isolated from clinical patients. Molecules 16(11): 9218-9233
Singh, I.P.; Mahajan, S. 2013: Berberine and its derivatives: a patent review (2009 - 2012). Expert Opinion on Therapeutic Patents 23(2): 215-231
Spinozzi, S.; Colliva, C.; Camborata, C.; Roberti, M.; Ianni, C.; Neri, F.; Calvarese, C.; Lisotti, A.; Mazzella, G.; Roda, A. 2014: Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. Journal of Natural Products 77(4): 766-772
Yang, N.; Wang, J.; Liu, C.; Song, Y.; Zhang, S.; Zi, J.; Zhan, J.; Masilamani, M.; Cox, A.; Nowak-Wegrzyn, A.; Sampson, H.; Li, X.-M. 2014: Berberine and limonin suppress IgE production by human B cells and peripheral blood mononuclear cells from food-allergic patients. Annals of Allergy Asthma and Immunology: Official Publication of the American College of Allergy Asthma and Immunology 113(5): 556-564.E4
Cicero, A.F.G.; Reggi, A.; Parini, A.; Morbini, M.; Rosticci, M.; Grandi, E.; Borghi, C. 2014: Berberine and monacolin effects on the cardiovascular risk profile of women with oestroprogestin-induced hypercholesterolemia. High Blood Pressure and Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension 21(3): 221-226
Zhang, J.; Yang, J.-Q.; He, B.-C.; Zhou, Q.-X.; Yu, H.-R.; Tang, Y.; Liu, B.-Z. 2009: Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease. Saudi Medical Journal 30(6): 760-766
Zhang, Y.-J.; Yang, S.-H.; Li, M.-H.; Iqbal, J.; Bourantas, C.V.; Mi, Q.-Y.; Yu, Y.-H.; Li, J.-J.; Zhao, S.-L.; Tian, N.-L.; Chen, S.-L. 2014: Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: role of autophagy. Clinical and Experimental Pharmacology and Physiology 41(12): 995-1002
Deng, Y.; Xu, J.; Zhang, X.; Yang, J.; Zhang, D.; Huang, J.; Lv, P.; Shen, W.; Yang, Y. 2014: Berberine attenuates autophagy in adipocytes by targeting BECN1. Autophagy 10(10): 1776-1786
Liu, X.; Zhou, J.; Abid, M.Dirhem.Naji.; Yan, H.; Huang, H.; Wan, L.; Feng, Z.; Chen, J. 2014: Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells. Plos one 9(4): E93974
Zhou, L.; Wang, X.; Yang, Y.; Wu, L.; Li, F.; Zhang, R.; Yuan, G.; Wang, N.; Chen, M.; Ning, G. 2011: Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes. Biochimica et Biophysica Acta 1812(4): 527-535
Yu, G.; Li, Y.; Tian, Q.; Liu, R.; Wang, Q.; Wang, J.-Z.; Wang, X. 2011: Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells. Journal of Alzheimer's Disease: Jad 24(3): 525-535
Dong, S.-F.; Hong, Y.; Liu, M.; Hao, Y.-Z.; Yu, H.-S.; Liu, Y.; Sun, J.-N. 2011: Berberine attenuates cardiac dysfunction in hyperglycemic and hypercholesterolemic rats. European Journal of Pharmacology 660(2-3): 368-374
Zhao, X.; Zhang, J.; Tong, N.; Liao, X.; Wang, E.; Li, Z.; Luo, Y.; Zuo, H. 2011: Berberine attenuates doxorubicin-induced cardiotoxicity in mice. Journal of International Medical Research 39(5): 1720-1727
Ma, X.; Jiang, Y.; Wu, A.; Chen, X.; Pi, R.; Liu, M.; Liu, Y. 2010: Berberine attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice. Plos one 5(10): E13489
Lan, T.; Wu, T.; Chen, C.; Chen, X.; Hao, J.; Huang, J.; Wang, L.; Huang, H. 2014: Berberine attenuates high glucose-induced proliferation and extracellular matrix accumulation in mesangial cells: involvement of suppression of cell cycle progression and NF-κB/AP-1 pathways. Molecular and Cellular Endocrinology 384(1-2): 109-116
Jiang, Q.; Liu, P.; Wu, X.; Liu, W.; Shen, X.; Lan, T.; Xu, S.; Peng, J.; Xie, X.; Huang, H. 2011: Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-κB signaling pathway. Molecular and Cellular Endocrinology 331(1): 34-40
Niu, L.; Qiao, W.; Hu, Z.; Li, N.; Huang, Q.; Gong, J.; Li, Q.; Zhu, W.; Li, J. 2011: Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat. Fitoterapia 82(3): 323-330
Li, N.; Gu, L.; Qu, L.; Gong, J.; Li, Q.; Zhu, W.; Li, J. 2010: Berberine attenuates pro-inflammatory cytokine-induced tight junction disruption in an in vitro model of intestinal epithelial cells. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 40(1): 1-8
Chen, H.; Chen, Y.; Tang, Y.; Yang, J.; Wang, D.; Yu, T.; Huang, C. 2014: Berberine attenuates spontaneous action potentials in sinoatrial node cells and the currents of human HCN4 channels expressed in Xenopus laevis oocytes. Molecular Medicine Reports 10(3): 1576-1582
Cannillo, M.; Frea, S.; Fornengo, C.; Toso, E.; Mercurio, G.; Battista, S.; Gaita, F. 2013: Berberine behind the thriller of marked symptomatic bradycardia. World Journal of Cardiology 5(7): 261-264
Winkler, A.; Puhl, M.; Weber, H.ör.; Kutchan, T.M.; Gruber, K.; Macheroux, P. 2009: Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to dehydroscoulerine. Phytochemistry 70(9): 1092-1097
Saha, P.; Sen, R.; Hariharan, C.; Kumar, D.; Das, P.; Chatterjee, M. 2009: Berberine chloride causes a caspase-independent, apoptotic-like death in Leishmania donovani promastigotes. Free Radical Research 43(11): 1101-1110
Saha, P.; Bhattacharjee, S.; Sarkar, A.; Manna, A.; Majumder, S.; Chatterjee, M. 2011: Berberine chloride mediates its anti-leishmanial activity via differential regulation of the mitogen activated protein kinase pathway in macrophages. Plos one 6(4): E18467
Fan, L.-x.; Liu, C.-m.; Gao, A.-h.; Zhou, Y.-b.; Li, J. 2013: Berberine combined with 2-deoxy-d-glucose synergistically enhances cancer cell proliferation inhibition via energy depletion and unfolded protein response disruption. Biochimica et Biophysica Acta 1830(11): 5175-5183
Chi, L.; Peng, L.; Hu, X.; Pan, N.; Zhang, Y. 2014: Berberine combined with atorvastatin downregulates LOX‑1 expression through the ET‑1 receptor in monocyte/macrophages. International Journal of Molecular Medicine 34(1): 283-290
Liu, J.; Xiu, J.; Cao, J.; Gao, Q.; Ma, D.; Fu, L. 2011: Berberine cooperates with adrenal androgen dehydroepiandrosterone sulfate to attenuate PDGF-induced proliferation of vascular smooth muscle cell A7r5 through Skp2 signaling pathway. Molecular and Cellular Biochemistry 355(1-2): 127-134
Shi, H.-L.; Wu, X.-J.; Liu, Y.; Xie, J.-Q. 2013: Berberine counteracts enhanced IL-8 expression of AGS cells induced by evodiamine. Life Sciences 93(22): 830-839
Wang, Y.; Yi, X.; Ghanam, K.; Zhang, S.; Zhao, T.; Zhu, X. 2014: Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption. Metabolism, Clinical and Experimental 63(9): 1167-1177
Chen, J.; Cao, J.; Fang, L.; Liu, B.; Zhou, Q.; Sun, Y.; Wang, Y.; Li, Y.; Meng, S. 2014: Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE(-/-) mice. Journal of Translational Medicine 12: 326
Huang, L.; Luo, Z.; He, F.; Shi, A.; Qin, F.; Li, X. 2010: Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase. Bioorganic and Medicinal Chemistry Letters 20(22): 6649-6652
Cui, G.; Qin, X.; Zhang, Y.; Gong, Z.; Ge, B.; Zang, Y.Q. 2009: Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice. Journal of Biological Chemistry 284(41): 28420-28429
Park, S.H.; Sung, J.H.; Chung, N. 2014: Berberine diminishes side population and down-regulates stem cell-associated genes in the pancreatic cancer cell lines PANC-1 and MIA PaCa-2. Molecular and Cellular Biochemistry 394(1-2): 209-215
Wang, L.-h.; Yu, C.-h.; Fu, Y.; Li, Q.; Sun, Y.-q. 2011: Berberine elicits anti-arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model. PhytoTherapy Research: Ptr 25(1): 33-37
Yu, M.; Tong, X.; Qi, B.; Qu, H.; Dong, S.; Yu, B.; Zhang, N.; Tang, N.; Wang, L.; Zhang, C. 2014: Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB. Molecular Medicine Reports 9(1): 249-254
Lin, T.-H.; Kuo, H.-C.; Chou, F.-P.; Lu, F.-J. 2008: Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. Bmc Cancer 8: 58
Yang, X.; Yang, B.; Cai, J.; Zhang, C.; Zhang, Q.; Xu, L.; Qin, Q.; Zhu, H.; Ma, J.; Tao, G.; Cheng, H.; Sun, X. 2013: Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo. Cancer Biology and Therapy 14(11): 1068-1073
Wojtyczka, R.D.; Dziedzic, A.; Kępa, M.łg.; Kubina, R.; Kabała-Dzik, A.; Mularz, T.; Idzik, D. 2014: Berberine enhances the antibacterial activity of selected antibiotics against coagulase-negative Staphylococcus strains in vitro. Molecules 19(5): 6583-6596
Refaat, A.; Abdelhamed, S.; Yagita, H.; Inoue, H.; Yokoyama, S.; Hayakawa, Y.; Saiki, I. 2013: Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer. Oncology Letters 6(3): 840-844
Gao, F.; Gao, Y.; Liu, Y.-F.; Wang, L.; Li, Y.-J. 2014: Berberine exerts an anticonvulsant effect and ameliorates memory impairment and oxidative stress in a pilocarpine-induced epilepsy model in the rat. Neuropsychiatric Disease and Treatment 10: 2139-2145
Domitrović, R.; Cvijanović, O.; Pernjak-Pugel, E.; Skoda, M.; Mikelić, L.; Crnčević-Orlić, Z. 2013: Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 62: 397-406
Cui, H.-S.; Matsumoto, K.; Murakami, Y.; Hori, H.; Zhao, Q.; Obi, R. 2009: Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression. Biological and Pharmaceutical Bulletin 32(1): 79-85
Li, X.; Zhao, S.-J.; Shi, H.-L.; Qiu, S.-P.; Xie, J.-Q.; Wu, H.; Zhang, B.-B.; Wang, Z.-T.; Yuan, J.-Y.; Wu, X.-J. 2014: Berberine hydrochloride IL-8 dependently inhibits invasion and IL-8-independently promotes cell apoptosis in MDA-MB-231 cells. Oncology Reports 32(6): 2777-2788
Feng, A.-W.; Yu, C.; Mao, Q.; Li, N.; Li, Q.-R.; Li, J.-S. 2011: Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. Fitoterapia 82(7): 976-982
Li, C.-H.; Wu, D.-F.; Ding, H.; Zhao, Y.; Zhou, K.-Y.; Xu, D.-F. 2014: Berberine hydrochloride impact on physiological processes and modulation of twist levels in nasopharyngeal carcinoma CNE-1 cells. Asian Pacific Journal of Cancer Prevention: Apjcp 15(4): 1851-1857
Zhang, Y.; Li, X.; Zhang, Q.; Li, J.; Ju, J.; Du, N.; Liu, X.; Chen, X.; Cheng, F.; Yang, L.; Xu, C.; Bilal, M.U.; Wei, Y.; Lu, Y.; Yang, B. 2014: Berberine hydrochloride prevents postsurgery intestinal adhesion and inflammation in rats. Journal of Pharmacology and Experimental Therapeutics 349(3): 417-426
Tan, W.; Li, Y.; Chen, M.; Wang, Y. 2011: Berberine hydrochloride: anticancer activity and nanoparticulate delivery system. International Journal of Nanomedicine 6: 1773-1777
Cheng, F.; Wang, Y.; Li, J.; Su, C.; Wu, F.; Xia, W-Hao.; Yang, Z.; Yu, B-Bo.; Qiu, Y-Xia.; Tao, J. 2013: Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans. International Journal of Cardiology 167(3): 936-942
Chen, Y.; Li, Y.; Wang, Y.; Wen, Y.; Sun, C. 2009: Berberine improves free-fatty-acid-induced insulin resistance in L6 myotubes through inhibiting peroxisome proliferator-activated receptor gamma and fatty acid transferase expressions. Metabolism, Clinical and Experimental 58(12): 1694-1702
Chen, Y.; Wang, Y.; Zhang, J.; Sun, C.; Lopez, A. 2011: Berberine improves glucose homeostasis in streptozotocin-induced diabetic rats in association with multiple factors of insulin resistance. Isrn Endocrinology 2011: 519371
Xia, X.; Yan, J.; Shen, Y.; Tang, K.; Yin, J.; Zhang, Y.; Yang, D.; Liang, H.; Ye, J.; Weng, J. 2011: Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis. Plos one 6(2): E16556
Yin, J.; Gao, Z.; Liu, D.; Liu, Z.; Ye, J. 2008: Berberine improves glucose metabolism through induction of glycolysis. American Journal of Physiology. Endocrinology and Metabolism 294(1): E148-E156
Yang, J.; Yin, J.; Gao, H.; Xu, L.; Wang, Y.; Xu, L.; Li, M. 2012: Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients. Evidence-Based Complementary and Alternative Medicine: Ecam 2012: 363845
Zhao, L.; Sun, L.-N.; Nie, H.-B.; Wang, X.-L.; Guan, G.-J. 2014: Berberine improves kidney function in diabetic mice via AMPK activation. Plos one 9(11): E113398
Ren, L-Ming.; Zhuo, Y-Jie.; Hao, Z-Sen.; He, H-Mei.; Lu, H-Gang.; Zhao, D. 2013: Berberine improves neurogenic contractile response of bladder detrusor muscle in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology 150(3): 1128-1136
Li, M-Hui.; Zhang, Y-Jun.; Yu, Y-Hui.; Yang, S-Hua.; Iqbal, J.; Mi, Q-Yu.; Li, B.; Wang, Z-Mei.; Mao, W-Xing.; Xie, H-Guang.; Chen, S-Liang. 2014: Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy. European Journal of Pharmacology 728: 67-76
Mittal, A.; Tabasum, S.; Singh, R.P. 2014: Berberine in combination with doxorubicin suppresses growth of murine melanoma B16F10 cells in culture and xenograft. Phytomedicine: International Journal of PhytoTherapy and Phytopharmacology 21(3): 340-347
Dong, H.; Wang, N.; Zhao, L.; Lu, F. 2012: Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine: Ecam 2012: 591654
Hu, Y.; Davies, G.E. 2009: Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation. Phytomedicine: International Journal of PhytoTherapy and Phytopharmacology 16(9): 864-873
Zhang, Y.; Wang, X.; Sha, S.; Liang, S.; Zhao, L.; Liu, L.; Chai, N.; Wang, H.; Wu, K. 2012: Berberine increases the expression of NHE3 and AQP4 in sennosideA-induced diarrhoea model. Fitoterapia 83(6): 1014-1022
Ho, Y.-T.; Lu, C.-C.; Yang, J.-S.; Chiang, J.-H.; Li, T.-C.; Ip, S.-W.; Hsia, T.-C.; Liao, C.-L.; Lin, J.-G.; Wood, W.G.; Chung, J.-G. 2009: Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells. Anticancer Research 29(10): 4063-4070
Zhu, Y.; Ma, N.; Li, H.-X.; Tian, L.; Ba, Y.-F.; Hao, B. 2014: Berberine induces apoptosis and DNA damage in MG‑63 human osteosarcoma cells. Molecular Medicine Reports 10(4): 1734-1738
Patil, J.B.; Kim, J.; Jayaprakasha, G.K. 2010: Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway. European Journal of Pharmacology 645(1-3): 70-78
Qing, Y.; Hu, H.; Liu, Y.; Feng, T.; Meng, W.; Jiang, L.; Sun, Y.; Yao, Y. 2014: Berberine induces apoptosis in human multiple myeloma cell line U266 through hypomethylation of p53 promoter. Cell Biology International 38(5): 563-570
Liu, J.; Zhang, X.; Liu, A.; Liu, S.; Zhang, L.; Wu, B.; Hu, Q. 2013: Berberine induces apoptosis in p53-null leukemia cells by down-regulating XIAP at the post-transcriptional level. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology Biochemistry and Pharmacology 32(5): 1213-1224
Yip, N.K.Y.; Ho, W.S. 2013: Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells. Oncology Reports 30(3): 1107-1112
Wang, N.; Feng, Y.; Zhu, M.; Tsang, C.-M.; Man, K.; Tong, Y.; Tsao, S.-W. 2010: Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism. Journal of Cellular Biochemistry 111(6): 1426-1436
Wang, L.; Liu, L.; Shi, Y.; Cao, H.; Chaturvedi, R.; Calcutt, M.W.; Hu, T.; Ren, X.; Wilson, K.T.; Polk, D.B.; Yan, F. 2012: Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. Plos one 7(5): E36418
Hou, Q.; Tang, X.; Liu, H.; Tang, J.; Yang, Y.; Jing, X.; Xiao, Q.; Wang, W.; Gou, X.; Wang, Z. 2011: Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147. Cancer Science 102(7): 1287-1292
Hu, Z.; Jiao, Q.; Ding, J.; Liu, F.; Liu, R.; Shan, L.; Zeng, H.; Zhang, J.; Zhang, W. 2011: Berberine induces dendritic cell apoptosis and has therapeutic potential for rheumatoid arthritis. Arthritis and Rheumatism 63(4): 949-959
Hu, X.; Wu, X.; Huang, Y.; Tong, Q.; Takeda, S.; Qing, Y. 2014: Berberine induces double-strand DNA breaks in Rev3 deficient cells. Molecular Medicine Reports 9(5): 1883-1888
Zhang, K.; Zhi, D.; Huang, T.; Gong, Y.; Yan, M.; Liu, C.; Wei, T.; Dong, Z.; Li, B.; Yang, B. 2014: Berberine induces hERG channel deficiency through trafficking inhibition. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology Biochemistry and Pharmacology 34(3): 691-702
Yang, X.; Huang, N. 2013: Berberine induces selective apoptosis through the AMPK‑mediated mitochondrial/caspase pathway in hepatocellular carcinoma. Molecular Medicine Reports 8(2): 505-510
Xiong, C-yin.; Fu, Y-hang.; Hu, H-bin.; Bi, A-fen.; Pei, D-cui. 2014: Berberine inhibited apoptosis of human umbilical vein endothelial cells induced by Staphylocoocus aureus: an experimental research. Zhongguo Zhong Xi Yi Jie he Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi 34(6): 710-713
Hur, J.-M.; Kim, D. 2010: Berberine inhibited radioresistant effects and enhanced anti-tumor effects in the irradiated-human prostate cancer cells. Toxicological Research 26(2): 109-115
Park, K.S.; Kim, J.B.; Bae, J.; Park, S.-Y.; Jee, H.-G.; Lee, K.E.; Youn, Y.-K. 2012: Berberine inhibited the growth of thyroid cancer cell lines 8505C and TPC1. Yonsei Medical Journal 53(2): 346-351
Zha, W.; Liang, G.; Xiao, J.; Studer, E.J.; Hylemon, P.B.; Pandak, W.M.; Wang, G.; Li, X.; Zhou, H. 2010: Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophages. Plos one 5(2): E9069
Gao, M.-y.; Chen, L.; Yang, L.; Yu, X.; Kou, J.-p.; Yu, B.-y. 2014: Berberine inhibits LPS-induced TF procoagulant activity and expression through NF-κB/p65, Akt and MAPK pathway in THP-1 cells. Pharmacological Reports: Pr 66(3): 480-484
Sarna, L.K.; Wu, N.; Hwang, S.-Y.; Siow, Y.L.; O, K. 2010: Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophages. Canadian Journal of Physiology and Pharmacology 88(3): 369-378
Chen, C.; Zhang, Y.; Huang, C. 2010: Berberine inhibits PTP1B activity and mimics insulin action. Biochemical and Biophysical Research Communications 397(3): 543-547
Hu, J.-P.; Nishishita, K.; Sakai, E.; Yoshida, H.; Kato, Y.; Tsukuba, T.; Okamoto, K. 2008: Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways. European Journal of Pharmacology 580(1-2): 70-79
Tsang, C.M.; Lau, E.P.W.; Di, K.; Cheung, P.Y.; Hau, P.M.; Ching, Y.P.; Wong, Y.C.; Cheung, A.L.M.; Wan, T.S.K.; Tong, Y.; Tsao, S.W.; Feng, Y. 2009: Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells. International Journal of Molecular Medicine 24(1): 131-138
Hu, Y.; Kutscher, E.; Davies, G.E. 2010: Berberine inhibits SREBP-1-related clozapine and risperidone induced adipogenesis in 3T3-L1 cells. PhytoTherapy Research: Ptr 24(12): 1831-1838
Wang, X.; Qiu, S.; Yao, X.; Tang, T.; Dai, K.; Zhu, Z.'a. 2009: Berberine inhibits Staphylococcus epidermidis adhesion and biofilm formation on the surface of titanium alloy. Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society 27(11): 1487-1492
Liu, Y.; Liu, S. 2013: Berberine inhibits Wilms' tumor cell progression through upregulation of Wilms' tumor gene on the X chromosome. Molecular Medicine Reports 8(5): 1537-1541
Li, G.-h.; Wang, D.-l.; Hu, Y.-d.; Pu, P.; Li, D.-z.; Wang, W.-d.; Zhu, B.; Hao, P.; Wang, J.; Xu, X.-q.; Wan, J.-q.; Zhou, Y.-b.; Chen, Z.-t. 2010: Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy. Medical Oncology 27(3): 919-925
Hu, Y.; Davies, G.E. 2010: Berberine inhibits adipogenesis in high-fat diet-induced obesity mice. Fitoterapia 81(5): 358-366
Jie, S.; Li, H.; Tian, Y.; Guo, D.; Zhu, J.; Gao, S.; Jiang, L. 2011: Berberine inhibits angiogenic potential of Hep G2 cell line through VEGF down-regulation in vitro. Journal of Gastroenterology and Hepatology 26(1): 179-185
Zhang, H.-q.; Wang, H.-d.; Lu, D.-x.; Qi, R.-b.; Wang, Y.-p.; Yan, Y.-x.; Fu, Y.-m. 2008: Berberine inhibits cytosolic phospholipase A2 and protects against LPS-induced lung injury and lethality independent of the alpha2-adrenergic receptor in mice. Shock 29(5): 617-622
Lv, X.; Yu, X.; Wang, Y.; Wang, F.; Li, H.; Wang, Y.; Lu, D.; Qi, R.; Wang, H. 2012: Berberine inhibits doxorubicin-triggered cardiomyocyte apoptosis via attenuating mitochondrial dysfunction and increasing Bcl-2 expression. Plos one 7(10): E47351
Xiao, H.-B.; Sun, Z.-L.; Zhang, H.-B.; Zhang, D.-S. 2012: Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation. Pharmacological Reports: Pr 64(4): 889-895
Zhu, S.-L.; Yan, L.; Zhang, Y.-X.; Jiang, Z.-H.; Gao, P.-H.; Qiu, Y.; Wang, L.; Zhao, M.-Z.; Ni, T.-J.-H.; Cai, Z.; Tian, S.-J.; Zang, C.-X.; Zhang, D.-Z.; Jiang, Y.-Y. 2014: Berberine inhibits fluphenazine-induced up-regulation of CDR1 in Candida albicans. Biological and Pharmaceutical Bulletin 37(2): 268-273
He, W.; Wang, B.; Zhuang, Y.; Shao, D.; Sun, K.; Chen, J. 2012: Berberine inhibits growth and induces G1 arrest and apoptosis in human cholangiocarcinoma QBC939 cells. Journal of Pharmacological Sciences 119(4): 341-348
Sun, X.; Zhang, X.; Hu, H.; Lu, Y.; Chen, J.; Yasuda, K.; Wang, H. 2009: Berberine inhibits hepatic stellate cell proliferation and prevents experimental liver fibrosis. Biological and Pharmaceutical Bulletin 32(9): 1533-1537
Liu, B.; Wang, G.; Yang, J.; Pan, X.; Yang, Z.; Zang, L. 2011: Berberine inhibits human hepatoma cell invasion without cytotoxicity in healthy hepatocytes. Plos one 6(6): E21416
Choi, M.S.; Yuk, D.Y.; Oh, J.H.; Jung, H.Y.; Han, S.B.; Moon, D.C.; Hong, J.T. 2008: Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis. Anticancer Research 28(6a): 3777-3784
Lou, T.; Zhang, Z.; Xi, Z.; Liu, K.; Li, L.; Liu, B.; Huang, F. 2011: Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes. Inflammation 34(6): 659-667
Zhou, X.; Zhang, C.; Wang, X.; An, B.; Zhang, P.; Zhu, Z'an. 2012: Berberine inhibits lipopolysaccharide- and polyethylene particle-induced mouse calvarial osteolysis in vivo. Journal of Surgical Research 173(2): E47-E52
Tang, F.; Wang, D.; Duan, C.; Huang, D.; Wu, Y.; Chen, Y.; Wang, W.; Xie, C.; Meng, J.; Wang, L.; Wu, B.; Liu, S.; Tian, D.; Zhu, F.; He, Z.; Deng, F.; Cao, Y. 2009: Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567. Journal of Biological Chemistry 284(40): 27456-27466
Choi, M.S.; Oh, J.H.; Kim, S.M.; Jung, H.Y.; Yoo, H.S.; Lee, Y.M.; Moon, D.C.; Han, S.B.; Hong, J.T. 2009: Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells. International Journal of Oncology 34(5): 1221-1230
Wang, L.; Cao, H.; Lu, N.; Liu, L.; Wang, B.; Hu, T.; Israel, D.A.; Peek, R.M.; Polk, D.B.; Yan, F. 2013: Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells. Plos one 8(2): E56666
Hamsa, T.P.; Kuttan, G. 2012: Berberine inhibits pulmonary metastasis through down-regulation of MMP in metastatic B16F-10 melanoma cells. PhytoTherapy Research: Ptr 26(4): 568-578
Chen, F.L.; Yang, Z.H.; Liu, Y.; Li, L.X.; Liang, W.C.; Wang, X.C.; Zhou, W.B.; Yang, Y.H.; Hu, R-Ming. 2008: Berberine inhibits the expression of TNFalpha, MCP-1, and IL-6 in AcLDL-stimulated macrophages through PPARgamma pathway. Endocrine 33(3): 331-337
Zhang, Q.; Zhang, C.; Yang, X.; Yang, B.; Wang, J.; Kang, Y.; Wang, Z.; Li, D.; Huang, G.; Ma, Z.; Sun, X.; Cai, J.; Tao, G.; Dai, S.; Mao, W.; Ma, J. 2014: Berberine inhibits the expression of hypoxia induction factor-1alpha and increases the radiosensitivity of prostate cancer. Diagnostic Pathology 9: 98
Huang, D.; Wang, W.; Feng, Z.; Wang, L.; Chen, Y.; Xie, C.; Meng, J.; Tang, F. 2011: Berberine inhibits the invasion and metastasis of nasopharyngeal carcinoma cells through Ezrin phosphorylation. Zhong Nan da Xue Xue Bao. Yi Xue Ban 36(7): 616-623
Wu, K.; Yang, Q.; Mu, Y.; Zhou, L.; Liu, Y.; Zhou, Q.; He, B. 2012: Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling. International Journal of Oncology 41(1): 292-298
Tan, W.; Li, N.; Tan, R.; Zhong, Z.; Suo, Z.; Yang, X.; Wang, Y.; Hu, X. 2015: Berberine interfered with breast cancer cells metabolism, balancing energy homeostasis. Anti-Cancer Agents in Medicinal Chemistry 15(1): 66-78
Zhou, Y.; Cao, S.; Wang, Y.; Xu, P.; Yan, J.; Bin, W.; Qiu, F.; Kang, N. 2014: Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells. Fitoterapia 92: 230-237
Germoush, M.O.; Mahmoud, A.M. 2014: Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines. Journal of Cancer Research and Clinical Oncology 140(7): 1103-1109
Zhang, Q.; Xiao, X.; Li, M.; Li, W.; Yu, M.; Zhang, H.; Ping, F.; Wang, Z.; Zheng, J. 2014: Berberine moderates glucose metabolism through the GnRH-GLP-1 and MAPK pathways in the intestine. Bmc Complementary and Alternative Medicine 14: 188
Pandey, M.K.; Sung, B.; Kunnumakkara, A.B.; Sethi, G.; Chaturvedi, M.M.; Aggarwal, B.B. 2008: Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. Cancer Research 68(13): 5370-5379
Derosa, G.; Maffioli, P.; Cicero, A.F.G. 2012: Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials. Expert Opinion on Biological Therapy 12(8): 1113-1124
Salehi, S.; Filtz, T.M. 2011: Berberine possesses muscarinic agonist-like properties in cultured rodent cardiomyocytes. Pharmacological Research 63(4): 335-340
Liu, B.; Wang, Q.; Yuan, D.-d.; Hong, X.-t.; Tao, L. 2011: Berberine potentizes apoptosis induced by X-rays irradiation probably through modulation of gap junctions. Chinese Medical Journal 124(8): 1221-1228
Zhang, J.; Cao, H.; Zhang, B.; Cao, H.; Xu, X.; Ruan, H.; Yi, T.; Tan, L.; Qu, R.; Song, G.; Wang, B.; Hu, T. 2013: Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling. Journal of Cellular and Molecular Medicine 17(11): 1484-1493
Manoharan, S.; Sindhu, G.; Vinothkumar, V.; Kowsalya, R. 2012: Berberine prevents 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis: a biochemical approach. European Journal of Cancer Prevention: the Official Journal of the European Cancer Prevention Organisation 21(2): 182-192
Li, G-xun.; Wang, X-mo.; Jiang, T.; Gong, J-feng.; Niu, L-ying.; Li, N. 2014: Berberine prevents damage to the intestinal mucosal barrier during early phase of sepsis in rat through mechanisms independent of the NOD-like receptors signaling pathway. European Journal of Pharmacology 730: 1-7
Wang, Y.; Huang, Y.; Lam, K.S.L.; Li, Y.; Wong, W.Tak.; Ye, H.; Lau, C-Wai.; Vanhoutte, P.M.; Xu, A. 2009: Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovascular Research 82(3): 484-492
Kim, M.; Cho, K-Ho.; Shin, M-Soon.; Lee, J-Min.; Cho, H-Sam.; Kim, C-Ju.; Shin, D-Hoon.; Yang, H.Jeong. 2014: Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson's disease. International Journal of Molecular Medicine 33(4): 870-878
Han, A.M.; Heo, H.; Kwon, Y.K. 2012: Berberine promotes axonal regeneration in injured nerves of the peripheral nervous system. Journal of Medicinal Food 15(4): 413-417
Lu, S.-S.; Yu, Y.-L.; Zhu, H.-J.; Liu, X.-D.; Liu, L.; Liu, Y.-W.; Wang, P.; Xie, L.; Wang, G.-J. 2009: Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats. Journal of Endocrinology 200(2): 159-165
Xu, M.; Xiao, Y.; Yin, J.; Hou, W.; Yu, X.; Shen, L.; Liu, F.; Wei, L.; Jia, W. 2014: Berberine promotes glucose consumption independently of AMP-activated protein kinase activation. Plos one 9(7): E103702
Yan, F.; Wang, L.; Shi, Y.; Cao, H.; Liu, L.; Washington, M.Kay.; Chaturvedi, R.; Israel, D.A.; Cao, H.; Wang, B.; Peek, R.M.; Wilson, K.T.; Polk, D.Brent. 2012: Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. American Journal of Physiology. Gastrointestinal and Liver Physiology 302(5): G504-G514
Bae, J.; Lee, D.; Kim, Y.K.; Gil, M.; Lee, J.-Y.; Lee, K.J. 2013: Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1. Molecules and Cells 35(2): 151-157
Bhutada, P.; Mundhada, Y.; Bansod, K.; Hiware, R.; Rathod, S.; Dixit, P.; Mundhada, D. 2011: Berberine protects C57BL/6J mice against ethanol withdrawal-induced hyperexcitability. PhytoTherapy Research: Ptr 25(2): 302-307
Choo, B.K.; Roh, S.-S. 2013: Berberine protects against esophageal mucosal damage in reflux esophagitis by suppressing proinflammatory cytokines. Experimental and Therapeutic Medicine 6(3): 663-670
Zhang, M.; Wang, C.-M.; Li, J.; Meng, Z.-J.; Wei, S.-N.; Li, J.; Bucala, R.; Li, Y.-L.; Chen, L. 2013: Berberine protects against palmitate-induced endothelial dysfunction: involvements of upregulation of AMPK and eNOS and downregulation of NOX4. Mediators of Inflammation 2013: 260464
Xiao, M.; Men, L.N.; Xu, M.G.; Wang, G.B.; Lv, H.T.; Liu, C. 2014: Berberine protects endothelial progenitor cell from damage of TNF-α via the PI3K/AKT/eNOS signaling pathway. European Journal of Pharmacology 743: 11-16
Chen, M.; Tan, M.; Jing, M.; Liu, A.; Liu, Q.; Wen, S.; Chen, Z.; Chao, X.; He, X.; Ramassamy, C.; Gao, Y.; Pi, R. 2015: Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway. Metabolic Brain Disease 30(1): 137-142
Zhang, W.; Su, X.; Gao, Y.; Sun, B.; Yu, Y.; Wang, X.; Zhang, F. 2009: Berberine protects mesenchymal stem cells against hypoxia-induced apoptosis in vitro. Biological and Pharmaceutical Bulletin 32(8): 1335-1342
Liu, Q.; Jiang, H.; Liu, Z.; Wang, Y.; Zhao, M.; Hao, C.; Feng, S.; Guo, H.; Xu, B.; Yang, Q.; Gong, Y.; Shao, C. 2011: Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51. Plos one 6(8): E23427
Zhang, C.; Yang, X.; Zhang, Q.; Yang, B.; Xu, L.; Qin, Q.; Zhu, H.; Liu, J.; Cai, J.; Tao, G.; Ma, J.; Ge, X.; Zhang, S.; Cheng, H.; Sun, X. 2014: Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression. Acta Oto-Laryngologica 134(2): 185-192
Huang, Z.; Wang, L.; Meng, S.; Wang, Y.; Chen, T.; Wang, C. 2011: Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages. International Journal of Cardiology 146(2): 153-158
Huang, K.; Liu, W.; Lan, T.; Xie, X.; Peng, J.; Huang, J.; Wang, S.; Shen, X.; Liu, P.; Huang, H. 2012: Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models. Plos one 7(8): E43874
Zhao, L.; Li, W.; Han, F.; Hou, L.; Baillargeon, J.-P.; Kuang, H.; Wang, Y.; Wu, X. 2011: Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro. Fertility and Sterility 95(1): 461-463
Kong, W-Jia.; Zhang, H.; Song, D-Qing.; Xue, R.; Zhao, W.; Wei, J.; Wang, Y-Ming.; Shan, N.; Zhou, Z-Xian.; Yang, P.; You, X-Fu.; Li, Z-Rong.; Si, S-Yi.; Zhao, L-Xun.; Pan, H-Ning.; Jiang, J-Dong. 2009: Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. Metabolism, Clinical and Experimental 58(1): 109-119
Dvorak, Z.; Vrzal, R. 2011: Berberine reduces insulin resistance: the roles for glucocorticoid receptor and aryl hydrocarbon receptor. Fertility and Sterility 95(2): E7; Author Reply E8-9
Chen, K.; Li, G.; Geng, F.; Zhang, Z.; Li, J.; Yang, M.; Dong, L.; Gao, F. 2014: Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K-Akt signaling in diabetic rats. Apoptosis: An International Journal on Programmed Cell Death 19(6): 946-957
Wu, Y.-H.; Chuang, S.-Y.; Hong, W.-C.; Lai, Y.-J.; Chang, G.-J.; Pang, J.-H.S. 2012: Berberine reduces leukocyte adhesion to LPS-stimulated endothelial cells and VCAM-1 expression both in vivo and in vitro. International Journal of Immunopathology and Pharmacology 25(3): 741-750
Chang, X.; Yan, H.; Fei, J.; Jiang, M.; Zhu, H.; Lu, D.; Gao, X. 2010: Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. Journal of Lipid Research 51(9): 2504-2515
Gu, L.; Li, N.; Yu, W.; Gong, J.; Li, Q.; Zhu, W.; Li, J. 2013: Berberine reduces rat intestinal tight junction injury induced by ischemia-reperfusion associated with the suppression of inducible nitric oxide synthesis. American Journal of Chinese Medicine 41(6): 1297-1312
Benaissa, F.; Mohseni-Rad, H.; Rahimi-Moghaddam, P.; Mahmoudian, M. 2009: Berberine reduces the hypoxic-ischemic insult in rat pup brain. Acta Physiologica Hungarica 96(2): 213-220
Ge, Y.; Zhang, Y.; Li, R.; Chen, W.; Li, Y.; Chen, G. 2011: Berberine regulated Gck, G6pc, Pck1 and Srebp-1c expression and activated AMP-activated protein kinase in primary rat hepatocytes. International Journal of Biological Sciences 7(5): 673-684
Li, W.; Hua, B.; Saud, S.M.; Lin, H.; Hou, W.; Matter, M.S.; Jia, L.; Colburn, N.H.; Young, M.R. 2015: Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice. Molecular Carcinogenesis 54(10): 1096-1109
Zhou, J.; Zhou, S. 2010: Berberine regulates peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in diabetic adipocytes. European Journal of Pharmacology 649(1-3): 390-397
Tang, L.Q.; Liu, S.; Zhang, S.T.; Zhu, L.N.; Wang, F.L. 2014: Berberine regulates the expression of E-prostanoid receptors in diabetic rats with nephropathy. Molecular Biology Reports 41(5): 3339-3347
Zhan, P.-Y.; Peng, C.-X.; Zhang, L.-H. 2014: Berberine rescues D-galactose-induced synaptic/memory impairment by regulating the levels of Arc. Pharmacology Biochemistry and Behavior 117: 47-51
Chu, S.-C.; Yu, C.-C.; Hsu, L.-S.; Chen, K.-S.; Su, M.-Y.; Chen, P.-N. 2014: Berberine reverses epithelial-to-mesenchymal transition and inhibits metastasis and tumor-induced angiogenesis in human cervical cancer cells. Molecular Pharmacology 86(6): 609-623
Yi, P.; Lu, F.-E.; Xu, L.-J.; Chen, G.; Dong, H.; Wang, K.-F. 2008: Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta. World Journal of Gastroenterology 14(6): 876-883
Teodoro, J.ão.S.; Duarte, F.V.; Gomes, A.P.íc.; Varela, A.T.; Peixoto, F.M.; Rolo, A.P.; Palmeira, C.M. 2013: Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation. Mitochondrion 13(6): 637-646
Lee, S.-J.; Noh, H.-J.; Sung, E.-G.; Song, I.-H.; Kim, J.-Y.; Kwon, T.K.; Lee, T.-J. 2011: Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins. International Journal of Oncology 38(2): 485-492
Tong, N.; Zhang, J.; Chen, Y.; Li, Z.; Luo, Y.; Zuo, H.; Zhao, X. 2012: Berberine sensitizes mutliple human cancer cells to the anticancer effects of doxorubicin in vitro. Oncology Letters 3(6): 1263-1267
Guo, N.; Yan, A.; Gao, X.; Chen, Y.; He, X.; Hu, Z.; Mi, M.; Tang, X.; Gou, X. 2014: Berberine sensitizes rapamycin‑mediated human hepatoma cell death in vitro. Molecular Medicine Reports 10(6): 3132-3138
Bonon, A.; Mangolini, A.; Pinton, P.; Del Senno, L.; Aguiari, G. 2013: Berberine slows cell growth in autosomal dominant polycystic kidney disease cells. Biochemical and Biophysical Research Communications 441(3): 668-674
Kim, S.; Choi, J.H.; Kim, J.B.; Nam, S.J.; Yang, J.-H.; Kim, J.-H.; Lee, J.E. 2008: Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells. Molecules 13(12): 2975-2985
Kim, S.; Oh, S.-J.; Lee, J.; Han, J.; Jeon, M.; Jung, T.; Lee, S.K.; Bae, S.Y.; Kim, J.; Gil, W.H.; Kim, S.W.; Lee, J.E.; Nam, S.J. 2013: Berberine suppresses TPA-induced fibronectin expression through the inhibition of VEGF secretion in breast cancer cells. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology Biochemistry and Pharmacology 32(5): 1541-1550
Yang, Y.; Qi, J.; Wang, Q.; Du, L.; Zhou, Y.; Yu, H.; Kijlstra, A.; Yang, P. 2013: Berberine suppresses Th17 and dendritic cell responses. Investigative Ophthalmology and Visual Science 54(4): 2516-2522
Jia, L.; Liu, J.; Song, Z.; Pan, X.; Chen, L.; Cui, X.; Wang, M. 2012: Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways. Journal of Pharmacy and Pharmacology 64(10): 1510-1521
Zhao, H.; Halicka, H.D.; Li, J.; Darzynkiewicz, Z. 2013: Berberine suppresses gero-conversion from cell cycle arrest to senescence. Aging 5(8): 623-636
Lan, T.; Liu, W.; Xie, X.; Huang, K.; Peng, J.; Huang, J.; Shen, X.; Liu, P.; Yang, H.; Huang, H. 2012: Berberine suppresses high glucose-induced TGF-β1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathway. European Journal of Pharmacology 697(1-3): 165-172
Liu, S.-j.; Yin, C.-x.; Ding, M.-c.; Xia, S.-y.; Shen, Q.-m.; Wu, J.-d. 2014: Berberine suppresses in vitro migration of human aortic smooth muscle cells through the inhibitions of MMP-2/9, u-PA, AP-1, and NF-κB. Bmb Reports 47(7): 388-392
Liu, L.; Yu, Y-Li.; Yang, J-Song.; Li, Y.; Liu, Y-Wu.; Liang, Y.; Liu, X-Dong.; Xie, L.; Wang, G-Ji. 2010: Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. Naunyn-Schmiedeberg's Archives of Pharmacology 381(4): 371-381
Lu, D.-Y.; Tang, C.-H.; Chen, Y.-H.; Wei, I.-H. 2010: Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia. Journal of Cellular Biochemistry 110(3): 697-705
Tsang, C.M.; Cheung, Y.C.; Lui, V.W.-Y.; Yip, Y.L.; Zhang, G.; Lin, V.W.; Cheung, K.C.-P.; Feng, Y.; Tsao, S.W. 2013: Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts. Bmc Cancer 13: 619
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Li, Z.; Jiang, J.-D.; Kong, W.-J. 2014: Berberine up-regulates hepatic low-density lipoprotein receptor through Ras-independent but AMP-activated protein kinase-dependent Raf-1 activation. Biological and Pharmaceutical Bulletin 37(11): 1766-1775
Simões Pires, E.N.; Frozza, R.L.; Hoppe, J.B.; Menezes, B.d.M.; Salbego, C.G. 2014: Berberine was neuroprotective against an in vitro model of brain ischemia: survival and apoptosis pathways involved. Brain Research 1557: 26-33
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Wang, Y.; Liu, Q.; Liu, Z.; Li, B.; Sun, Z.; Zhou, H.; Zhang, X.; Gong, Y.; Shao, C. 2012: Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells. Mutation Research 734(1-2): 20-29
Hsu, Y-Yun.; Tseng, Y-Ting.; Lo, Y-Ching. 2013: Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth. Toxicology and Applied Pharmacology 272(3): 787-796
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Singh, T.; Vaid, M.; Katiyar, N.; Sharma, S.; Katiyar, S.K. 2011: Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E₂ and prostaglandin E₂ receptors. Carcinogenesis 32(1): 86-92
Kuo, H.-P.; Chuang, T.-C.; Tsai, S.-C.; Tseng, H.-H.; Hsu, S.-C.; Chen, Y.-C.; Kuo, C.-L.; Kuo, Y.-H.; Liu, J.-Y.; Kao, M.-C. 2012: Berberine, an isoquinoline alkaloid, inhibits the metastatic potential of breast cancer cells via Akt pathway modulation. Journal of Agricultural and Food Chemistry 60(38): 9649-9658
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Li, G-Sheng.; Liu, X-Han.; Zhu, H.; Huang, L.; Liu, Y-Li.; Ma, C-Mei.; Qin, C. 2011: Berberine-improved visceral white adipose tissue insulin resistance associated with altered sterol regulatory element-binding proteins, liver x receptors, and peroxisome proliferator-activated receptors transcriptional programs in diabetic hamsters. Biological and Pharmaceutical Bulletin 34(5): 644-654
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Wang, J-mei.; Yang, Z.; Xu, M-guo.; Chen, L.; Wang, Y.; Su, C.; Tao, J. 2009: Berberine-induced decline in circulating CD31+/CD42- microparticles is associated with improvement of endothelial function in humans. European Journal of Pharmacology 614(1-3): 77-83
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