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Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery

Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery

Chemical Communications 47(18): 5232-5234

Mesoporous titania nanoparticles (MTNs) with excellent biocompatibility (LC(50)≈ 400 μg mL(-1)) and a large surface area (ca. 237.3 m(2) g(-1)) were synthesized and further functionalized with a phosphate-containing fluorescent molecule (i.e. flavin mononucleotide; FMN) and loaded with an anticancer drug (i.e. Doxorubicin) for successful intracellular bioimaging and drug delivery, respectively, in human breast cancer cells BT-20.

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Accession: 051802745

Download citation: RISBibTeXText

PMID: 21451853

DOI: 10.1039/c1cc10659g

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