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Bioinspired colorimetric detection of calcium(II) ions in serum using calsequestrin-functionalized gold nanoparticles

Bioinspired colorimetric detection of calcium(II) ions in serum using calsequestrin-functionalized gold nanoparticles

Angewandte Chemie 48(23): 4138-4141

Seeing is sensing: Calsequestrin (CSQ) functionalized gold nanoparticles undergo calcium-dependent CSQ polymerization, which results in a clear color change (see picture) together with precipitation. The sensing system is specific for Ca(2+) ions and the differences between normal and disease-associated abnormal (hypercalcemia) Ca(2+) ion levels in serum can be distinguished with the naked eye.

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Accession: 051807946

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PMID: 19425025

DOI: 10.1002/anie.200900071

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