+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Biomedical activities of endohedral metallofullerene optimized for nanopharmaceutics

Biomedical activities of endohedral metallofullerene optimized for nanopharmaceutics

Journal of Nanoscience and Nanotechnology 10(12): 8610-8616

Endohedral metallofullerenes, a novel form of carbon-related nanomaterials, currently attract wide attention for their potential applications in biomedical fields such as therapeutic medicine. Most endohedral metallofullerenes are synthesized using C60 or higher molecular weight fullerenes because of the limited interior volume of fullerene. It is known that the encapsulated metal atom has strong electronic interactions with the carbon cage in metallofullerenes. Gd@C82 is one of the most important molecules in the metallofullerene family, known as Magnetic Resonance Imaging (MRI) contrast agent candidate for diagnostic imaging. Gadolinium endohedral metallofullerenol (e.g., Gd@C82(OH)22) is a functionalized fullerene with gadolinium trapped inside carbon cage. Our group previously demonstrated that the distinctive chemical and physical properties of Gd@C82(OH)22 are dependent on the number and position of the hydroxyl groups on the fullerene cage. The present article summarizes our latest findings of biomedical effects of Gd@C82(OH)22 and gives rise to a connected flow of the existing knowledge and information from experts in the field. It briefly narrates the synthesis and physico-chemical properties of Gd@C82(OH)22. The polyhydroxylated nanoparticles exhibit the enhanced water solubility and high purity, and were tested as a MRI contrast agent. Gd@C82(OH)22 treatment inhibited tumor growth in tumor-bearing nude mice. Although the precise mechanisms of this action are not well defined, our in vitro data suggest involvements of improved immunity and antioxidation by Gd@C82(OH)22 and its size-based selective targeting to tumor site. The review critically analyzed the relevant data instead of fact-listing, and explained the potential for developing Gd@C82(OH)22 into a diagnostic or therapeutic agent.

(PDF emailed within 0-6 h: $19.90)

Accession: 051816766

Download citation: RISBibTeXText

PMID: 21121373

DOI: 10.1166/jnn.2010.2691

Related references

A Scandium Carbide Endohedral Metallofullerene: (Sc2 C2 )@C84. Angewandte Chemie 40(2): 397-399, 2018

Nanorods of endohedral metallofullerene derivative. Journal of the American Chemical Society 130(2): 450-451, 2007

Endohedral metallofullerene Sc3NC@C84: a theoretical prediction. Physical Chemistry Chemical Physics 14(43): 15099-15105, 2012

The structural determination of endohedral metallofullerene Gd@C(82) by XANES. Chemical Communications: 474-476, 2008

Synthesis of silylene-bridged endohedral metallofullerene Lu3N@I(h)-C80. Journal of the American Chemical Society 134(38): 16033-9, 2013

Radical coupling reaction of paramagnetic endohedral metallofullerene La@C82. Journal of the American Chemical Society 130(48): 16224-16230, 2008

Determination of molar extinction coefficients for endohedral metallofullerene Dy@C82(C2v). Russian Chemical Bulletin 65(10): 2421-2424, 2016

Ti2C80 is more likely a titanium carbide endohedral metallofullerene (Ti2C2)@C78. Chemical Communications: 4444-4446, 2005

La3N@C92: An Endohedral Metallofullerene Governed by Kinetic Factors?. Inorganic Chemistry 55(7): 3302-3306, 2016

Single molecular orientation switching of an endohedral metallofullerene. Nano Letters 5(6): 1057-1060, 2005

The 4d4f dipole resonance of the Pr atom in an endohedral metallofullerene, Pr@C82. Journal of Quantitative Spectroscopy and Radiative Transfer 109(9): 1590-1598, 2008

Synthesis of endohedral metallofullerene glycoconjugates by carbene addition. Molecules 16(11): 9495-9504, 2012

Studies of dipalmitoylphosphatidylcholine (DPPC) monolayers embedded with endohedral metallofullerene (Dy@C82). Langmuir 25(22): 12968-12973, 2009

Voltammetric behavior of water-soluble endohedral metallofullerene derivatives. Electroanalysis 17(2): 178-181, 2005

A singly bonded derivative of endohedral metallofullerene: La@C82CBr(COOC2H5). Journal of the American Chemical Society 127(49): 17136-7, 2005