+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Brain structural differences of schizophrenia patients with and without family histories

Brain structural differences of schizophrenia patients with and without family histories

Sichuan Da Xue Xue Bao. Yi Xue Ban 39(1): 39-43

To identify the brain structural differences of schizophrenia patients and their parents between those with family history and those sporadic cases. High resolution T1 weighted images were obtained using 3T MR from 10 familial patients and 10 sporadic patients matched with age, sex, years of education and duration of disease. All patients were in their first episode of care. Twenty unaffected parents of the patients (8 for familial cases, 12 for sporadic cases) and 20 normal controls were also examined. The images were preprocessed according to the optimized VBM protocol. Student t test was performed to test the differences of the gray matter density (GMD) of the patients and their parents between the groups with and without family histories, and between the patient groups and the normal controls. Compared with the sporadic group, significant reduce of GMD was observed in bilateral thalamus in both familial schizophrenia patients and their parents. Compared with normal controls, both familial and sporadic schizophrenia patients showed lower GMD in many areas including bilateral insula, right temporal lobe, right occipital lobe, left lenticula, right cerebellum and left rectal gyrus extending to anterior cingulated gyrus. Only familial patients showed lower GMD in the right thalamus. Familial parents also showed lower GMD in several areas including right insula extending to right temporal lobe and right parietal lobule. Familial schizophrenia is associated with genetically related structural abnormalities, especially in the bilateral thalamus. The brain structural differences can explain, at least in part, the symptom differences between familial and sporadic schizophrenia.

(PDF emailed within 1 workday: $29.90)

Accession: 051857816

Download citation: RISBibTeXText

PMID: 18390196

Related references

Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry. European Archives of Psychiatry and Clinical Neuroscience 254(6): 406-414, 2004

Structural abnormalities of the brain in schizophrenia: sex differences in the Cantabria First Episode of Schizophrenia Study. Psychological Medicine 25(6): 1247-1257, 1995

Running in the Family? Structural Brain Abnormalities and IQ in Offspring, Siblings, Parents, and Co-twins of Patients with Schizophrenia. Schizophrenia Bulletin 2019, 2019

Structural brain differences between never-treated patients with schizophrenia, with and without dyskinesia, and normal control subjects: a magnetic resonance imaging study. Archives of General Psychiatry 59(4): 332-336, 2002

Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. Archives of General Psychiatry 43(1): 36-42, 1986

Structural brain abnormalities in schizophrenia: A family study. Biological Psychiatry 42(12): 1080-1086, 1997

Family history and schizophrenia: characteristics of groups with and without positive family histories. Psychological Medicine 12(3): 591-594, 1982

The Maudsley Family Study I: Structural brain changes on magnetic resonance imaging in familial schizophrenia. Progress in Neuro Psychopharmacology and Biological Psychiatry 21(8): 1297-1315, 1997

The Maudsley Family Study. I: Structural brain changes on magnetic resonance imaging in familial schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 21(8): 1297-1315, 1998

Structural brain abnormalities in first-episode psychosis: differences between affective psychoses and schizophrenia and relationship to clinical outcome. Bipolar Disorders 13(5-6): 545-555, 2012

Integrated Analysis and Visualization of Group Differences in Structural and Functional Brain Connectivity: Applications in Typical Ageing and Schizophrenia. Plos One 10(9): E0137484, 2016

Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging. Archives of General Psychiatry 59(2): 154-164, 2002

Structural differences in hippocampal subfields among schizophrenia patients, major depressive disorder patients, and healthy subjects. Psychiatry Research. Neuroimaging 259: 54-59, 2016

Schizophrenia as a chronic active brain process: A study of progressive brain structural change subsequent to the onset of schizophrenia. Psychiatry Research 74(3): 129-140, 1997

Graph Metrics of Structural Brain Networks in Individuals with Schizophrenia and Healthy Controls: Group Differences, Relationships with Intelligence, and Genetics. Journal of the International Neuropsychological Society 22(2): 240-249, 2017