+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Brain structural imaging correlates of olfactory dysfunction in obsessive-compulsive disorder



Brain structural imaging correlates of olfactory dysfunction in obsessive-compulsive disorder



European Archives of Psychiatry and Clinical Neuroscience 264(3): 225-233



Olfactory dysfunction has been described in obsessive-compulsive disorder (OCD). Brain regions involved in smell processing partially overlap with structures included in the neurobiological models of OCD, although no previous studies have analyzed the neuroanatomical correlates of olfactory dysfunction in this disorder. The aim of our study was to examine the association between regional gray matter volume, as assessed by a voxel-based morphometry analysis of magnetic resonance images (MRI), and olfactory function, as assessed by the Sniffin' Sticks test (SST). Olfactory function was assessed in 19 OCD patients and 19 healthy volunteers. All participants were also scanned in a 1.5-T magnet to obtain T1-weighted anatomical MRIs, which were pre-processed and analyzed with SPM8. Three different correlation models were used to study the association between regional gray matter volumes and olfactory function in the domains assessed by the SST: detection threshold, discrimination, and identification. OCD patients showed a significant impairment in all the domains assessed by the SST. Voxel-based mapping revealed a positive association in healthy controls between detection threshold and the gray matter content of a left anterior cingulate cortex cluster. In OCD patients, a positive correlation was observed between identification errors and the gray matter volume of the left medial orbital gyrus. In a post hoc analysis, these two gray matter regions were shown to be enlarged in OCD patients. Our findings support the idea that olfactory dysfunction in OCD is associated with volumetric changes in brain areas typically implicated in the neurobiology of the disorder.

(PDF emailed within 0-6 h: $19.90)

Accession: 051857817

Download citation: RISBibTeXText

PMID: 23995893

DOI: 10.1007/s00406-013-0439-7


Related references

Orbitofrontal cortex dysfunction in obsessive-compulsive disorder? II. Olfactory quality discrimination in obsessive-compulsive disorder. European Neuropsychopharmacology 9(5): 415-420, Sept, 1999

Brain structural correlates of depressive comorbidity in obsessive-compulsive disorder. Neuroimage 38(3): 413-421, 2007

Brain structural correlates of sensory phenomena in patients with obsessive-compulsive disorder. Journal of Psychiatry & Neuroscience 40(4): 232-240, 2016

Brain structural correlates of obsessive-compulsive disorder with and without preceding stressful life events. World Journal of Biological Psychiatry 17(5): 366-377, 2016

Structural and functional brain imaging findings in obsessive-compulsive disorder. Duodecim; Laaketieteellinen Aikakauskirja 114(8): 755-759, 2001

Structural brain MR imaging changes associated with obsessive-compulsive disorder in patients with multiple sclerosis. Ajnr. American Journal of Neuroradiology 34(2): 305-309, 2013

Prevalence and correlates of obsessive-compulsive disorder and subthreshold obsessive-compulsive disorder among college students in Kerala, India. Indian Journal of Psychiatry 59(1): 56-62, 2017

Orbitofrontal cortex dysfunction in obsessive-compulsive disorder? I. Alternation learning in obsessive-compulsive disorder: Male-female comparisons. European Neuropsychopharmacology 9(5): 407-413, Sept, 1999

NEUROIMAGING OF SUBCORTICAL BRAIN VOLUME ALTERATIONS IN PEADIATRIC AND ADULT OBSESSIVE-COMPULSIVE DISORDER: Preliminary findings from the ENIGMA Obsessive-Compulsive Disorder working group. European Neuropsychopharmacology 27(6): 617-619, 2017

Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates. Comprehensive Psychiatry 46(1): 14-19, 2005

The correlates of obsessive-compulsive, schizotypal, and borderline personality disorders in obsessive-compulsive disorder. Journal of Anxiety Disorders 33: 15-24, 2016

Childhood, adolescent and adult age at onset and related clinical correlates in obsessive-compulsive disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS). International Journal of Psychiatry in Clinical Practice 20(4): 210-217, 2016

Frontal abnormalities in a patient with obsessive-compulsive disorder: the role of structural lesions in obsessive-compulsive behavior. Neurology 45(12): 2130-2134, 1995

Comorbidity of obsessive-compulsive disorder with obsessive-compulsive personality disorder: Does it imply a specific subtype of obsessive-compulsive disorder?. Psychiatry Research 177(1-2): 156-160, 2010

Brain microstructural changes and cognitive correlates in patients with pure obsessive compulsive disorder. Brain and Behavior 4(2): 261-277, 2014