+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Breast cancer after hormone replacement therapy--does prognosis differ in perimenopausal and postmenopausal women?



Breast cancer after hormone replacement therapy--does prognosis differ in perimenopausal and postmenopausal women?



Breast 20(5): 448-454



Hormone replacement therapy (HRT) has been associated with higher incidence of breast cancer in postmenopausal women, but it is unclear if breast cancers developing after HRT use have different prognosis. 1053 women with hormone receptor positive non-metastasized breast cancer were analyzed in a retrospective trial, stratifying by HRT use before diagnosis. Postmenopausal HRT users had significantly more early tumor stages (p<0.001). HRT in postmenopausal patients was associated with longer time to progression (TTP) (HR 0.81, 95%CI 0.55-1.19, p=0.28) and overall survival (OS) (HR 0.68, 95%CI 0.45-1.02, p=0.059). Perimenopausal HRT users showed shorter TTP and OS (HR 1.99, 95%CI 0.57-6.91, p=0.28 and HR 4.59, 95%CI 0.91-23.25, p=0.06 respectively). Higher BMI was significantly associated with poorer prognosis in perimenopausal women only (TTP: HR=1.16; OS: HR=1.31). In this retrospective analysis postmenopausal HRT users seemed to have a better breast cancer prognosis. For perimenopausal HRT users however, a trend towards worse prognosis was found.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 051861762

Download citation: RISBibTeXText

PMID: 21652211

DOI: 10.1016/j.breast.2011.04.010


Related references

Adjuvant endocrine therapy of perimenopausal and recently postmenopausal women with hormone receptor-positive breast cancer. Clinical Breast Cancer 14(3): 147-153, 2015

Study of tumor S-phase in postmenopausal women diagnosed with breast cancer while using hormone replacement therapy vs those never having used hormone replacement therapy. Proceedings of the American Association for Cancer Research Annual Meeting 37(0): 203, 1996

Effect of hormone replacement therapy on lipids in perimenopausal and early postmenopausal women. Maturitas 39(3): 209-216, September 28, 2001

Mammographic density changes in perimenopausal and postmenopausal women: Is effect of hormone replacement therapy predictable?. Breast Cancer Research & Treatment 59(2): 125-132, 2000

Attitudes towards and level of information on perimenopausal and postmenopausal hormone replacement therapy among Norwegian women. Maturitas. 15(3): 183-194, 1992

Hormone replacement therapy and the risk of breast cancer among postmenopausal women. American Journal of Epidemiology 153(11 Supplement): S34, June 1, 2001

Hormone replacement therapy in peri- and postmenopausal women and breast cancer risk. Therapeutische Umschau. Revue Therapeutique 65(4): 231-234, 2008

Current breast cancer risks of hormone replacement therapy in postmenopausal women. Expert Opinion on PharmacoTherapy 7(18): 2455-2463, 2006

Transdermal nicotine use in postmenopausal women: Does the treatment efficacy differ in women using and not using hormone replacement therapy?. Nicotine & Tobacco Research 6(5): 777-788, 2004

Transdermal nicotine use in postmenopausal women: does the treatment efficacy differ in women using and not using hormone replacement therapy?. Nicotine & Tobacco Research 6(5): 777-788, 2005

Oral health in perimenopausal and early postmenopausal women from baseline to 2 years of follow-up with reference to hormone replacement therapy. Clinical Oral Investigations 12(3): 271-277, 2008

Hormone replacement therapy dependent changes in breast cancer-related gene expression in breast tissue of healthy postmenopausal women. Molecular Oncology 5(6): 504-516, 2012

Re: "Long-term hormone replacement therapy and risk of breast cancer in postmenopausal women". American Journal of Epidemiology 144(8): 798-799, 1996

Hormone replacement therapy and some risk factors for breast cancer among Slovenian postmenopausal women. Climacteric 14(4): 458-463, 2011

Controversies over hormone replacement therapy. HRT as a risk factor of breast cancer in postmenopausal women. Acta Poloniae Pharmaceutica 62(3): 241-247, 2005