+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

CD25 expression on cutaneous mast cells from adult patients presenting with urticaria pigmentosa is predictive of systemic mastocytosis

CD25 expression on cutaneous mast cells from adult patients presenting with urticaria pigmentosa is predictive of systemic mastocytosis

American Journal of Surgical Pathology 32(1): 139-145

Urticaria pigmentosa (UP) is a clinicopathologic term used to describe reddish-brown cutaneous macules and papules, characterized histologically by mast cell infiltration of the papillary and upper reticular dermis and reactive basal hyperpigmentation of the overlying epidermis. Although typically a benign, self-limited disorder of childhood, a significant proportion (up to 30%) of adolescent and adult-onset UP represents cutaneous involvement by underlying systemic mastocytosis (SM). Predicting the course of cutaneous mast cell disease has been limited by a lack of diagnostic and prognostic markers. In patients with SM, neoplastic bone marrow mast cells show aberrant surface expression of CD25. However, whether CD25 expression on cutaneous mast cells is associated with underlying SM is unknown. In this study, we performed a clinicopathologic analysis of 30 adult patients presenting with UP between 1987 and 2007. Cutaneous mast cell infiltration pattern, cytomorphology, density, and CD25 immunoreactivity were correlated with underlying or subsequent SM. On the basis of clinical and pathologic follow-up, 10 of 30 (33%) patients were diagnosed with SM and 20 of 30 (67%) with limited cutaneous mastocytosis (CM). Although cutaneous mast cell density was slightly higher in patients with SM compared to those with limited CM (P=0.047), neither mast cell cytomorphology nor infiltration pattern correlated with underlying systemic disease. However, cutaneous mast cells from all 10 patients with SM (100%) were immunoreactive for CD25, compared to only 5 of 20 (25%) with limited CM (P<0.001). Our findings suggest that immunoreactivity for CD25 in cutaneous mast cells may be useful for stratifying adult patients presenting with UP for additional clinical evaluation.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 051889145

Download citation: RISBibTeXText

PMID: 18162781

DOI: 10.1097/pas.0b013e3180ca9a02

Related references

Does the aberrant expression of CD2 and CD25 by skin mast cells truly correlate with systemic involvement in patients presenting with mastocytosis in the skin?. International Archives of Allergy and Immunology 165(2): 104-110, 2015

Immunohistochemical characterization of human cutaneous mast cells in urticaria pigmentosa (cutaneous mastocytosis). Acta Pathologica Japonica 41(5): 344-349, 1991

Intestinal mucosal mast cells enumeration in urticaria pigmentosa and systemic mastocytosis. British Journal of Dermatology 119(5): 573-578, 1988

CD25 expression in cutaneous mast cell lesions: Differential expression in cutaneous and systemic mastocytosis. 2008

Evolution of urticaria pigmentosa into indolent systemic mastocytosis: abnormal immunophenotype of mast cells without evidence of c-kit mutation ASP-816-VAL. Leukemia and Lymphoma 44(2): 313-319, 2003

P5: Systemic Mastocytosis Presenting As Cardiac Tamponade With Cd25 + Pericardial Mast Cells. Journal of Investigative Medicine 64(3): 819.1-819, 2016

Systemic mastocytosis presenting as cardiac tamponade with CD25(+) pericardial mast cells. Clinical Case Reports 4(3): 279-281, 2016

Regression of urticaria pigmentosa in adult patients with systemic mastocytosis: correlation with clinical patterns of disease. Archives of Dermatology 138(6): 785-790, 2002

Mastocytosis. Main symptoms of cutaneous mastocytosis: urticaria pigmentosa. Praxis 94(36): 1373-9; Quiz 1380, 2005

Response of cutaneous mast cells to PUVA in patients with urticaria pigmentosa: histomorphometric, ultrastructural, and biochemical investigations. Journal of Investigative Dermatology 83(3): 175-178, 1984

Expression of CD2 and CD25 on mast cell populations can be seen outside the setting of systemic mastocytosis. Cytometry. Part B, Clinical Cytometry 90(4): 387-392, 2017

The remarkable tissue mast cells; with observations on mast cell acid polysaccharides in the cutaneous lesions of urticaria pigmentosa. Archives of Dermatology 80: 725-730, 1959

Adult-onset urticaria pigmentosa and systemic mast cell disease. American Journal of Clinical Pathology 84(6): 710-714, 1985

The bone marrow in urticaria pigmentosa and systemic mastocytosis cell composition and mast cell density in relation to urinary excretion to tele methylimidazoleacetic acid. Archives of Dermatology 122(4): 422-427, 1986

Diagnostic value of immunohistochemical detection of CD25 in neoplastic mast cells of systemic mastocytosis. Modern Pathology 16(1): 236A, 2003