+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Campylobacter jejuni is not merely a commensal in commercial broiler chickens and affects bird welfare



Campylobacter jejuni is not merely a commensal in commercial broiler chickens and affects bird welfare



Mbio 5(4): E01364-14



Campylobacter jejuni is the leading cause of bacterial food-borne infection; chicken meat is its main source. C. jejuni is considered commensal in chickens based on experimental models unrepresentative of commercial production. Here we show that the paradigm of Campylobacter commensalism in the chicken is flawed. Through experimental infection of four commercial breeds of broiler chickens, we show that breed has a significant effect on C. jejuni infection and the immune response of the animals, although these factors have limited impact on the number of bacteria in chicken ceca. All breeds mounted an innate immune response. In some breeds, this response declined when interleukin-10 was expressed, consistent with regulation of the intestinal inflammatory response, and these birds remained healthy. In another breed, there was a prolonged inflammatory response, evidence of damage to gut mucosa, and diarrhea. We show that bird type has a major impact on infection biology of C. jejuni. In some breeds, infection leads to disease, and the bacterium cannot be considered a harmless commensal. These findings have implications for the welfare of chickens in commercial production where C. jejuni infection is a persistent problem. Importance: Campylobacter jejuni is the most common cause of food-borne bacterial diarrheal disease in the developed world. Chicken is the most common source of infection. C. jejuni infection of chickens had previously not been considered to cause disease, and it was thought that C. jejuni was part of the normal microbiota of birds. In this work, we show that modern rapidly growing chicken breeds used in intensive production systems have a strong inflammatory response to C. jejuni infection that can lead to diarrhea, which, in turn, leads to damage to the feet and legs on the birds due to standing on wet litter. The response and level of disease varied between breeds and is related to regulation of the inflammatory immune response. These findings challenge the paradigm that C. jejuni is a harmless commensal of chickens and that C. jejuni infection may have substantial impact on animal health and welfare in intensive poultry production:

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 051912922

Download citation: RISBibTeXText

PMID: 24987092

DOI: 10.1128/mbio.01364-14


Related references

Reduced spread of Campylobacter jejuni in broiler chickens by stimulating the bird's natural barriers. Journal of Applied Microbiology 113(5): 1176-1183, 2012

Associations between animal welfare indicators and Campylobacter spp. in broiler chickens under commercial settings: A case study. Preventive Veterinary Medicine 147: 186-193, 2017

Associations between animal welfare indicators and Campylobacter spp. in broiler chickens under commercial settings: A case study. Preventive Veterinary Medicine 147: 186-193, 2017

Application of a Group Ii Campylobacter Bacteriophage To Reduce Strains of Campylobacter jejuni and Campylobacter coli Colonizing Broiler Chickens. Journal of Food Protection 72(4): 733-740, 2009

Application of a group II Campylobacter bacteriophage to reduce strains of Campylobacter jejuni and Campylobacter coli colonizing broiler chickens. Journal of Food Protection 72(4): 733-740, 2009

Efficacy of a mucosal anti-Campylobacter jejuni vaccine administered with and without Escherichia coli heat labile toxin in one day to two week old commercial broiler chickens. Abstracts of the General Meeting of the American Society for Microbiology 96: 271, 1996

Detection of Campylobacter jejuni strains in the water lines of a commercial broiler house and their relationship to the strains that colonized the chickens. Avian Diseases 47(1): 101-107, 2003

Detection of Campylobacter jejuni Strains in the Water Lines of a Commercial Broiler House and Their Relationship to the Strains That Colonized the Chickens. Avian Diseases 47(1): 101-107, 2003

Evaluation of Salmonella-vectored Campylobacter peptide epitopes for reduction of Campylobacter jejuni in broiler chickens. Clinical and Vaccine Immunology 18(3): 449-454, 2011

Diversity of pulsed-field gel electrophoresis profiles of Campylobacter jejuni and Campylobacter coli from broiler chickens in France. Poultry Science 87(8): 1662-1671, 2008

Antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolates from broiler chickens isolated at an Irish poultry processing plant. Letters in Applied Microbiology 36(5): 277-281, 2003

Campylobacter jejuni Infection in Broiler Chickens. Avian Diseases 50(1): 55-58, 2006

Campylobacter jejuni infection in broiler chickens. Avian Diseases 50(1): 55-58, 2006

Allyl isothiocyanate exerts anti-Campylobacter and general antimicrobial properties on commercial broiler breast meat treated with Campylobacter jejuni and stored at 4degreeC. Poultry Science 80(7): 1024-1025, 2001

Colonization of broiler chickens by waterborne Campylobacter jejuni. Applied and Environmental Microbiology 59(4): 987-996, 1993