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Carbaporphyrin ketals as potential agents for a new photodynamic therapy treatment of leishmaniasis



Carbaporphyrin ketals as potential agents for a new photodynamic therapy treatment of leishmaniasis



Bioorganic and Medicinal Chemistry 16(14): 7033-7038



Dimethyl and diethyl carbaporphyrin ketals inhibit the growth of Leishmania tarentolae promastigotes in vitro. The concentration dependency of the inhibitory effect was tested using the MTT assay. The presence of reactive oxygen species, such as singlet oxygen and superoxide, was detected using electron paramagnetic resonance spectroscopy with selected spin traps and confocal microscopy in cultures exposed to these carbaporphyrin ketals. These unique porphyrinoids show promise as potent inhibitors of Leishmania.

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Accession: 051933369

Download citation: RISBibTeXText

PMID: 18541431

DOI: 10.1016/j.bmc.2008.05.037


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