+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Casting for determinants of blastocyst yield and of rates of implantation and of pregnancy after blastocyst transfers



Casting for determinants of blastocyst yield and of rates of implantation and of pregnancy after blastocyst transfers



Fertility and Sterility 102(4): 1055-1064



To identify determinants of blastocyst yield, implantation rate, and pregnancy outcome. Retrospective analysis of outcomes of 1,653 cycles of IVF. Private infertility clinic. Couples presenting to an infertility clinic for IVF. None. Blastocyst yield, implantation rate, and pregnancy. Of a broad array of potential determinants, only the total numbers of oocytes retrieved and properties of day 3 embryos were consistently predictive of blastocyst formation. Relative to numbers of oocytes fertilized by intracytoplasmic sperm injection (ICSI), yields of quality blastocysts were highest in cycles in which <10 oocytes were retrieved. Blastocyst yield was closely linearly correlated with average numbers of blastomeres in embryos on day 3. As oocyte yields rose, average grades and the implantation potential of the blastocysts selected for transfer increased by approximately 0.015 and 0.15%, respectively, for each additional oocyte. Independently, the implantation potential of blastocysts decreased 1.1% for each advancing year in age of the oocyte provider, and, for autologous transfers, uterine receptivity declined an additional 0.6% per year. Higher yields of blastocysts from cycles with high oocyte numbers afforded better selection of blastocysts for transfer, supporting higher overall implantation and pregnancy rates. While the proportion of fertilized oocytes that progressed to quality blastocysts diminished as numbers of recovered oocytes rose, rates of implantation and pregnancy after transfer of the selected best blastocysts increased. The age of the oocyte provider and oocyte yields independently impacted blastocyst implantation potential and uterine receptivity after controlled ovarian hyperstimulation, ICSI, and blastocyst transfer.

(PDF emailed within 0-6 h: $19.90)

Accession: 051967608

Download citation: RISBibTeXText

PMID: 25108462

DOI: 10.1016/j.fertnstert.2014.06.049


Related references

Higher clinical pregnancy rates from frozen-thawed blastocyst transfers compared to fresh blastocyst transfers: a retrospective matched-cohort study. Journal of Assisted Reproduction and Genetics 32(10): 1483-1490, 2016

Efficacy of hyaluronan-rich transfer medium on implantation and pregnancy rates in fresh and frozen-thawed blastocyst transfers in Korean women with previous implantation failure. Obstetrics and Gynecology Science 59(3): 201-207, 2016

Vitrified-warmed blastocyst transfer cycles yield higher pregnancy and implantation rates compared with fresh blastocyst transfer cycles--time for a new embryo transfer strategy?. Fertility and Sterility 95(5): 1691-1695, 2011

Can blastocyst expansion morphokinetics be useful in selecting a single embryo? a retrospective study of double blastocyst transfers in donor egg blastocyst recipients. Fertility and Sterility 106(3): E317-E318, 2016

Blastocyst score affects implantation and pregnancy outcome: Towards a single blastocyst transfer. Fertility & Sterility 73(6): 1155-1158, 2000

Comparison of clinical outcomes following vitrified warmed day 5/6 blastocyst transfers using solid surface methodology with fresh blastocyst transfers. Journal of Human Reproductive Sciences 6(1): 59-64, 2013

Ratio between inner cell mass diameter and blastocyst diameter is correlated with successful pregnancy outcomes of single blastocyst transfers. Fertility and Sterility 106(6): 1386-1391, 2016

Blastocyst quality, pregnancy and multiple gestation rates Is it feasible yet to transfer a single blastocyst to a selected patient population?. Human Reproduction 16(Abstract Book 1): 127, 2001

How to maximize the pregnancy rate with no increase in multiple pregnancy rates following blastocyst embryo transfer? Is blastocyst transfer time the missing ingredient?. Middle East Fertility Society Journal 20(4): 241-245, 2015

Day 5 blastocyst stage is directly proportional to pregnancy and implantation rates. Fertility & Sterility 80(Suppl 3): S99, 2003

Are there ethnic differences in pregnancy rates in African-American versus white women undergoing frozen blastocyst transfers?. Fertility and Sterility 95(1): 89-93, 2011

Two-blastocyst transfer has similar pregnancy rates and a decreased multiple gestation rate compared with three-blastocyst transfer. Fertility & Sterility 72(2): 225-228, 1999

Transfer of spontaneously hatching or hatched blastocyst yields better pregnancy rates than expanded blastocyst transfer. Journal of Human Reproductive Sciences 6(3): 183-188, 2013

Comparison of pregnancy and implantation rates for blastocyst transfer after ICSI and routine IVF. Human Reproduction 15(Abstract Book 1): 149, 2000

Implantation and pregnancy rates are higher for oocyte donor cycles after blastocyst-stage embryo transfer. Fertility and Sterility 77(6): 1296-1297, 2002