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Catalytic enantioselective desymmetrization of meso cyclic anhydrides via iridium-catalyzed hydrogenation

Catalytic enantioselective desymmetrization of meso cyclic anhydrides via iridium-catalyzed hydrogenation

Organic Letters 15(7): 1740-1743

A novel method to desymmetrize meso-anhydrides into lactones via asymmetric hydrogenation catalyzed by the Ir-C3*-TunePhos complex has been developed. Various chiral lactones were synthesized with full conversion and excellent enantioselectivity under high reaction temperature.

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Accession: 051969433

Download citation: RISBibTeXText

PMID: 23485036

DOI: 10.1021/ol400533g

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