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Catalytic enantioselective desymmetrization of meso-diamines: a dual small-molecule catalysis approach



Catalytic enantioselective desymmetrization of meso-diamines: a dual small-molecule catalysis approach



Journal of the American Chemical Society 133(37): 14538-14541



The desymmetrization of meso-diamines was accomplished via enantioselective monobenzoylation facilitated by the cooperative action of two small-molecule catalysts. A chiral acyl-transfer reagent is formed in situ through the interplay of benzoic anhydride, 4-(dimethylamino)pyridine as a nucleophilic catalyst, and a chiral amide-thiourea cocatalyst.

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Accession: 051969434

Download citation: RISBibTeXText

PMID: 21863902

DOI: 10.1021/ja2060462


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