+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cell entry mechanism of coronaviruses: implication in their pathogenesis

Cell entry mechanism of coronaviruses: implication in their pathogenesis

Uirusu 56(2): 165-171

Coronaviruses infect many species of animals, including humans. Among them, murine coronavirus, mouse hepatitis virus (MHV) has been well studied as a model of human diseases, such as hepatitis and demyelinating disease. An agent causing severe acute respiratory disease (SARS), SARS coronavirus (SARS-CoV), is a newcomer in this genus, however, it is now one of the most studied coronaviruses due to its medical impact. The receptors of those two viruses have been identified and their cell entry mechanism has been actively investigated. Recently, SARS-CoV cell entry mechanism is shown to be different from that of other enveloped viruses, including MHV. In this review, cell entry mechanism of those two viruses is described, stressing on the difference and similarity found between those two viruses.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 051981192

Download citation: RISBibTeXText

PMID: 17446665

Related references

Cell entry mechanism of coronaviruses: Implication in their pathogenesis. Virus 56(2): 165-171, 2006

Protease-dependent cell entry mechanism of coronaviruses. Uirusu 61(1): 109-116, 2011

Cell entry mechanisms of coronaviruses. Uirusu 59(2): 215-222, 2009

Molecular mechanism of pathogenesis of dengue virus: Entry and fusion with target cell. Indian Journal of Clinical Biochemistry 20(2): 92, 2005

Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy. Diabetes 54(10): 2952-2960, 2005

DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry. Journal of Virology 88(20): 12087-12097, 2014

Herpesvirus entry mediator on radiation-resistant cell lineages promotes ocular herpes simplex virus 1 pathogenesis in an entry-independent manner. Mbio 6(5): E01532, 2015

Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses. Virologica Sinica 31(1): 49-56, 2016

The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication. American Journal of Translational Research 2(3): 316-331, 2010

Isolation and diagnosis of coronaviruses as a factor in bovine shipping fever, and a cell line for culturing both those and other bovine coronaviruses. Official Gazette of the United States Patent & Trademark Office Patents 1193(1): 422, 1996

Therapies for coronaviruses. Part I of II -- viral entry inhibitors. Expert Opinion on Therapeutic Patents 19(3): 357-367, 2009

Coronaviruses induce entry-independent, continuous macropinocytosis. Mbio 5(4): E01340, 2014

Pathogenesis and treatment of diabetic neuropathy on the basis of vascular implication mechanism of action of prostaglandin e 1 analogues. Journal of the Japan Diabetes Society 33(2): 115-123, 1990

Mechanism of intestinal entry of infectious prion protein in the pathogenesis of variant Creutzfeldt-Jakob disease. Advanced Drug Delivery Reviews 56(6): 915-920, 2004

Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Archives of Biochemistry and Biophysics 500(2): 203-209, 2010