+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Cell-mediated immune responses to a varicella-zoster virus glycoprotein e vaccine using both a TLR agonist and QS21 in mice

Cell-mediated immune responses to a varicella-zoster virus glycoprotein e vaccine using both a TLR agonist and QS21 in mice

Vaccine 30(20): 3126-3135

ISSN/ISBN: 0264-410X

PMID: 22326899

DOI: 10.1016/j.vaccine.2012.01.088

Lack of adequate cell-mediated immunity (CMI) to varicella-zoster virus (VZV) has been associated with higher risks of developing herpes zoster (HZ) and associated post-herpetic neuralgia (PHN), and is of particular concern for older and immunocompromised individuals. Thus, the development of an effective HZ vaccine with a clinically acceptable safety profile that is capable of addressing decreased immunity would be highly desirable. In this study we compared the immunogenicity of different vaccine formulations containing VZV glycoprotein E (gE), an important target for CMI and antibody responses, in a VZV-primed mouse model. The formulations included recombinant gE, either unadjuvanted, or combined with aluminium salt or an Adjuvant System (AS01 or AS02), and CMI was used as the primary immunological endpoint. All adjuvanted vaccines induced gE- and/or VZV-specific CD4(+) T cell and antibody responses. A formulation of gE with an Adjuvant System containing the immunostimulants QS21 and 3-O-desacyl-4'-monophosphoryl lipid A (MPL) was shown to be more immunogenic than gE with aluminium salt or unadjuvanted gE (gE/saline). Both immunostimulants were shown to act synergistically in enhancing CMI responses. Formulations with AS01 elicited high frequencies of CD4(+) T cells producing IFN-γ and IL-2. These responses were dose-dependent with respect to both antigen and adjuvant. The gE/AS01(B) candidate vaccine induced higher frequencies of CD4(+) T cells producing IL-2 and/or IFN-γ than all other gE/AS01 formulations, supporting its use for clinical evaluations.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 051984027

Download citation: RISBibTeXText

Related references

Comparison of a glycoprotein E-based ELISA with a varicella-zoster whole-virus ELISA for the quantification of varicella vaccine immune responses in young children. Vaccine 38(17): 3300-3304, 2020

Baculovirus Display of Varicella-Zoster Virus Glycoprotein e Induces Robust Humoral and Cellular Immune Responses in Mice. Viruses 14(8), 2022

Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine. Journal of Infectious Diseases 200(7): 1068-1077, 2009

Booster vaccination of healthy adults with varicella zoster virus antibody but without a varicella zoster virus specific cell mediated immune response. Antiviral Research 1: 267-272, 1985

Humoral and cell mediated responses to a DNA expression vector encoding the varicella zoster virus glycoprotein E gene. Immunology 95(Suppl 1): 17, 1998

Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine. Journal of Infectious Diseases 197(6): 825-835, 2008

Varicella-zoster virus-specific cell-mediated immune responses in HIV-infected adults. Aids Research and Human Retroviruses 27(10): 1089-1097, 2011

Varicella-Zoster Virus-Specific Cellular Immune Responses to the Live Attenuated Zoster Vaccine in Young and Older Adults. Journal of Immunology 199(2): 604-612, 2017

Influence of age and nature of primary infection on varicella-zoster virus-specific cell-mediated immune responses. Journal of Infectious Diseases 201(7): 1024-1030, 2010

Boosting immune response with a candidate varicella-zoster virus glycoprotein subunit vaccine. Vaccine 13(14): 1336-1338, 1995

Varicella zoster virus-specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medications. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 56(8): 1085-1093, 2013

Efficient induction of cell-mediated immunity to varicella-zoster virus glycoprotein e co-lyophilized with a cationic liposome-based adjuvant in mice. Vaccine 37(15): 2131-2141, 2019

Immunogenicity in mice of varicella-zoster virus glycoprotein i expressed by a vaccinia virus-varicella-zoster virus recombinant. Journal of General Virology 72: 1445-1449, 1991

Immunogenicity in mice of varicella-zoster virus glycoprotein I expressed by a vaccina virus-varicella-zoster virus recombinant. Journal of General Virology 72(6): 1445-1449, 1991

Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine. Journal of Infectious Diseases 219(2): 335-338, 2019