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Characterization and antibacterial properties of genipin-crosslinked chitosan/poly(ethylene glycol)/ZnO/Ag nanocomposites

Characterization and antibacterial properties of genipin-crosslinked chitosan/poly(ethylene glycol)/ZnO/Ag nanocomposites

Carbohydrate Polymers 89(1): 111-116

ISSN/ISBN: 0144-8617

PMID: 24750611

DOI: 10.1016/j.carbpol.2012.02.058

Novel nanocomposites consisting of genipin-crosslinked chitosan (GC), poly(ethylene glycol) (PEG), zinc oxide (ZnO), and silver (Ag) nanoparticles were prepared for biomedical applications as the wound-healing materials. Various amounts of ZnO and Ag nanoparticles were dispersed in the GC/PEG hydrogel matrix without severe aggregation. The effects of composition and ZnO nanoparticles on the physico-chemical properties of nanocomposite samples were evaluated by infrared analysis, X-ray diffraction, and scanning electron microscopy. GC/PEG/ZnO/Ag nanocomposite showed the pH-sensitive swelling behavior and the improved mechanical properties. The antibacterial activities of nanocomposite films were tested toward the bacterial species Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis. GC/PEG/ZnO/Ag composite films had higher antibacterial activities than GC/PEG and GC/PEG/ZnO nanocomposite films. GC/PEG/ZnO/Ag composite films have potential application as wound and burn dressings.

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Accession: 052025672

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