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Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm

Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm

Angewandte Chemie 48(29): 5309-5312

Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).

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Accession: 052042612

Download citation: RISBibTeXText

PMID: 19294716

DOI: 10.1002/anie.200900064

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