+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Chlorhexidine-silver sulfadiazine-impregnated central venous catheters: in vitro antibacterial activity and impact on bacterial adhesion



Chlorhexidine-silver sulfadiazine-impregnated central venous catheters: in vitro antibacterial activity and impact on bacterial adhesion



New Microbiologica 35(2): 175-182



The aim of this study was to compare the in vitro activity and the impact on bacterial adhesion of two different catheters, one impregnated with chlorhexidine-silver sulfadiazine (C-SS) and the other not impregnated with antibacterial agents. The antimicrobial coating prevented the bacterial colonization by slime positive Staphylococcus epidermidis in the first two days. The antibacterial activity of the effluents from catheters impregnated with C-SS dissipated by day seven. Our results demonstrated that the surface treatment modified the composition of impregnated catheters and determined different contact angle values of the two catheters (impregnated and not impregnated). Examination of coated and uncoated catheter segments by scanning electron microscopy showed a good correlation with the results of adherence experiments. In conclusion, the findings suggest that C-SS coated catheters prevent in vitro bacterial adhesion.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 052066445

Download citation: RISBibTeXText

PMID: 22707130


Related references

Impact of chlorhexidine-silver sulfadiazine-impregnated central venous catheters on in vitro quantitation of catheter-associated bacteria. Journal of Clinical Microbiology 34(10): 2640-2641, 1996

Effectiveness of Minocycline/Rifampin vs Chlorhexidine/Silver Sulfadiazine-Impregnated Central Venous Catheters. Journal of the American College of Surgeons 221(4): 891-892, 2015

Inhibitory effect of explanted chlorhexidine-silver sulfadiazine impregnated central venous catheters on Staphylococcus epidermidis. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 40: 422, 2000

Evaluation of chlorhexidine and silver-sulfadiazine impregnated central venous catheters for the prevention of bloodstream infection in leukaemic patients: a randomized controlled trial. Journal of Hospital Infection 37(2): 145-156, 1997

The effectiveness of chlorhexidine-silver sulfadiazine impregnated central venous catheters in patients receiving high-dose chemotherapy followed by peripheral stem cell transplantation. European Journal of Cancer Care 18(5): 477-482, 2009

Chlorhexidine-silver sulfadiazine-impregnated venous catheters save costs. American Journal of Infection Control 42(3): 321-324, 2014

Effectiveness of Minocycline and Rifampin vs Chlorhexidine and Silver Sulfadiazine-Impregnated Central Venous Catheters in Preventing Central Line-Associated Bloodstream Infection in a High-Volume Academic Intensive Care Unit: A Before and after Trial. Journal of the American College of Surgeons 221(3): 739-747, 2015

Efficiency of chlorhexidine-silver sulfadiazine-impregnated venous catheters at subclavian sites. American Journal of Infection Control 43(7): 711-714, 2015

Double-lumen central venous catheters impregnated with chlorhexidine and silver sulfadiazine to prevent catheter colonisation in the intensive care unit setting: a prospective randomised study. Journal of Hospital Infection 72(3): 227-233, 2009

Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unit with a low blood stream infection rate after implementation of an educational program: a before-after trial. Surgical Infections 8(4): 445-454, 2007

Chlorhexidine-silver sulfadiazine-impregnated venous catheters are efficient even at subclavian sites without tracheostomy. American Journal of Infection Control 44(12): 1526-1529, 2016

Decreased bacterial adherence and biofilm formation on chlorhexidine and silver sulfadiazine-impregnanted central venous catheters implanted in swine. Critical Care Medicine 23(5): 894-900, 1995

Cost/benefit analysis of chlorhexidine-silver sulfadiazine-impregnated venous catheters for femoral access. American Journal of Infection Control 42(10): 1130-1132, 2014

Measurement of ultrasonic-induced chlorhexidine liberation: correlation of the activity of chlorhexidine-silver-sulfadiazine-impregnated catheters to agar roll technique and broth culture. Journal of Hospital Infection 44(2): 141-145, 2000

Intravascular placement of silver sulfadiazine-chlorhexidine impregnated catheters in swine Evaluation of biofilm formation and bacterial adherence. Program & Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 33: 415, 1993