+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Chloroquine inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis



Chloroquine inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis



Cancer Investigation 27(3): 286-292



The present study was to investigate the anticancer effect of chloroquine on proliferation of mouse colon cancer cell line CT26 in vivo and in vitro and the possible mechanism. We found that chloroquine inhibited CT26 proliferation by concentration- and time-dependent manner. This effect was associated with apoptosis induction and decreased level of phosphorylated p42/44 mitogen-activated protein kinase and phosphorylated Akt. The in vivo study showed chloroquine-reduced tumor volume and prolonged survival time in CT26-bearing mice. These observations indicated chloroquine could inhibit CT26 proliferation by inducing apoptosis both in vitro and in vivo, providing its chemotherapeutic potential of human cancers.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052067362

Download citation: RISBibTeXText

PMID: 19194831

DOI: 10.1080/07357900802427927


Related references

Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis. Cellular Physiology and Biochemistry 27(3-4): 233-242, 2011

Tian Xian Liquid (TXL) induces apoptosis in HT-29 colon cancer cell in vitro and inhibits tumor growth in vivo. Chinese Medicine 5: 25, 2010

The TF-antigen binding lectin from Sclerotium rolfsii inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivo. Glycobiology 22(9): 1227-1235, 2012

Hinokitiol inhibits cell growth through induction of S-phase arrest and apoptosis in human colon cancer cells and suppresses tumor growth in a mouse xenograft experiment. Journal of Natural Products 76(12): 2195-2202, 2013

ShRNA-mediated insulin-like growth factor I receptor gene silencing inhibits cell proliferation, induces cell apoptosis, and suppresses tumor growth in non-small cell lung cancer: in vitro and in vivo experiments. Zhonghua Yi Xue Za Zhi 87(21): 1506-1509, 2007

Hydroquinone analog 4-[(Tetrahydro-2H-pyran-2‑yl) oxy] phenol induces C26 colon cancer cell apoptosis and inhibits tumor growth in vivo. Molecular Medicine Reports 11(6): 4671-4677, 2015

Glucuronorhamnoxylan from Capsosiphon fulvescens inhibits the growth of HT-29 human colon cancer cells in vitro and in vivo via induction of apoptotic cell death. International Journal of Biological Macromolecules 124: 1060-1068, 2019

Duchesnea phenolic fraction inhibits in vitro and in vivo growth of cervical cancer through induction of apoptosis and cell cycle arrest. Experimental Biology and Medicine 234(1): 74-83, 2009

Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest. International Journal of Oncology 30(6): 1529-1537, 2007

24-Methyl-Cholesta-5,24(28)-Diene-3β,19-diol-7β-Monoacetate Inhibits Human Small Cell Lung Cancer Growth In Vitro and In Vivo via Apoptosis Induction. Marine Drugs 15(7):, 2017

Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. Cancer Science 101(2): 488-493, 2010

Oc.10.5 In Vitro And In Vivo Knock-Down Of Smad7 Inhibits Growth And Promotes Apoptosis Of Colon Cancer Cells. Digestive and Liver Disease 45: S78-S79, 2013

LL-202, a newly synthesized flavonoid, inhibits tumor growth via inducing G(2)/M phase arrest and cell apoptosis in MCF-7 human breast cancer cells in vitro and in vivo. Toxicology Letters 228(1): 1-12, 2014

Mo1160 In Vitro and In Vivo Knock-Down of Smad7 Inhibits Growth and Promotes Apoptosis of Colon Cancer Cells. Gastroenterology 144(5): S-595, 2013

Enterolactone induces apoptosis and inhibits growth of Colo 201 human colon cancer cells both in vitro and in vivo. Anticancer Research 25(3b): 2269-2276, 2005