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Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats



Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats



Toxicology 298(1-3): 1-13



In order to assess the potential chronic toxicity and tumorigenicity of ammonium perfluorooctanoate (APFO), a two-year dietary study was conducted with male and female rats fed 3 or 3ppm (approximately 1.5 and 15mg/kg). In males fed 3ppm, mean body weights were lower across most of the test period and survival in these rats was greater than that seen either in the 3ppm or the control group. Non-neoplastic effects were observed in liver in rats fed 3ppm and included elevated liver weight, an increase in the incidence of diffuse hepatocellular hypertrophy, portal mononuclear cell infiltration, mild hepatocellular vacuolation without hepatocellular necrosis. Mean serum activities of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase were elevated up to three times the control means, primarily at the 3ppm dose. A significant increase in Leydig cell tumors of the testes was seen in the males fed 3ppm, and tumors of the liver and acinar pancreas, which are often observed in rats from chronic exposure to peroxisome proliferating agents, were not observed in this study. All other tumor types were those seen spontaneously in rats of this stock and age and were not associated with feeding of APFO.

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Accession: 052078135

Download citation: RISBibTeXText

PMID: 22531602

DOI: 10.1016/j.tox.2012.04.001



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