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Circulating microRNA-19a as a potential novel biomarker for diagnosis of acute myocardial infarction



Circulating microRNA-19a as a potential novel biomarker for diagnosis of acute myocardial infarction



International Journal of Molecular Sciences 15(11): 20355-20364



Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses were carried out by grouping of disease types and stratification of risk factors. Receiver-operator characteristic curve analysis was used to compare the current common clinical biochemical markers and evaluate the sensitivity and specificity of miR-19a for diagnosing AMI. Circulating miR-19a expression in the AMI group was higher than that in controls. The diagnostic effect of circulating miR-19a levels was superior to current clinical biochemical indices, such as CK, CK-MB, MYO, hs-TnI, and BNP. Our results show that there is a close association of circulating miR-19a levels with susceptibility to AMI. Circulating miR-19a levels could be a candidate diagnostic biomarker for AMI.

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Accession: 052091040

Download citation: RISBibTeXText

PMID: 25383678

DOI: 10.3390/ijms151120355


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