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Clinical and immunological features of acute hepatitis B in patients with concomitant chronic toxic liver damage

Clinical and immunological features of acute hepatitis B in patients with concomitant chronic toxic liver damage

Georgian Medical News 2013(215): 46-51

The article presents information obtained during the survey in 64 patients with acute hepatitis B. We show that acute hepatitis B in patients with concomitant chronic toxic liver characterized by a marked imbalance of cytokine status due to a lower level of interleukin-2 and a higher content of interleukin-8, the highest levels of nitrite content, spontaneous oxidative modifications of blood proteins and the lowest content of L -arginine in the blood serum in the dynamics of disease compared with patients without this concomitant factor. In the period of convalescence these changes in patients with acute hepatitis B with concomitant chronic toxic liver characterized combined with higher cytolysis of liver cells, often circulating in the blood of HBsAg seroconversion and less frequently with the advent of anti-HBeAg.

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Accession: 052106580

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PMID: 23482362

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